Costimulation Blockade in Kidney Transplant Recipients
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DOI: 10.1007/s40265-019-01226-6
Abstract: Costimulation between T cells and antigen-presenting cells is essential for the regulation of an effective alloimmune response and is not targeted with the conventional immunosuppressive therapy after kidney transplantation. Costimulation blockade therapy with biologicals allows… read more here.
Keywords: kidney transplant; transplant recipients; costimulation blockade; costimulation ... See more keywords
IL-6 inhibition prevents costimulation blockade-resistant allograft rejection in T cell-depleted recipients by promoting intragraft immune regulation in mice
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DOI: 10.1038/s41467-024-48574-w
Abstract: The efficacy of costimulation blockade with CTLA4-Ig (belatacept) in transplantation is limited due to T cell-mediated rejection, which also persists after induction with anti-thymocyte globulin (ATG). Here, we investigate why ATG fails to prevent costimulation… read more here.
Keywords: blockade resistant; blockade; rejection; costimulation blockade ... See more keywords
Corticosteroids and methotrexate as adjuvants to costimulation blockade in non‐human primate renal transplantation
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DOI: 10.1111/ctr.13568
Abstract: Belatacept, the CD28‐B7 costimulation pathway inhibitor, has been approved as a calcineurin inhibitor (CNI) alternative in kidney transplantation. Although costimulation blockade (CoB) allows for CNI avoidance, it is associated with increased rates of early rejection,… read more here.
Keywords: kidney transplantation; costimulation blockade; transplantation; costimulation ... See more keywords