A costimulatory molecule-related signature in regard to evaluation of prognosis and immune features for clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00646-2
Abstract: Costimulatory molecules have been proven to enhance antitumor immune responses, but their roles in clear cell renal cell carcinoma (ccRCC) remain unexplored. In this study, we aimed to explore the gene expression profiles of costimulatory… read more here.
Keywords: costimulatory; costimulatory molecule; clear cell; signature ... See more keywords
A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaw7888
Abstract: CD28 bispecific antibodies are well tolerated and enhance the antitumor efficacy of CD3 bispecifics as a potential off-the-shelf antibody therapy. Double trouble for tumors Bispecific antibodies, which have one arm that binds to a cancer… read more here.
Keywords: cd3; cd28; costimulatory; bispecific antibodies ... See more keywords
Abstract 3582: Inclusion of a Dap10 costimulatory domain enhances anti-tumor efficacy of chimeric PD1-expressing T cells in multiple types of solid tumors
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1158/1538-7445.am2018-3582
Abstract: Adoptive transfer of tumor-reactive T cells is a promising anti-tumor therapy for many cancers. To enhance tumor recognition by T cells, chimeric antigen receptors (CAR) consisting of signaling domains fused to receptors that recognize tumor… read more here.
Keywords: chpd1; costimulatory; anti tumor; receptor ... See more keywords
Abstract 1788: A novel costimulatory signaling domain for chimeric antigen receptor-engineering
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1788
Abstract: Chimeric antigen receptor (CAR)-engineered adoptive cell therapy has demonstrated a feasible, attractive “off-the-shelf” approach against various malignancies. Success of CAR-engineered cell therapy depends primarily on providing optimized costimulatory signals capable of achieving robust cell proliferation,… read more here.
Keywords: antigen receptor; signaling domain; chimeric antigen; car ... See more keywords
A Costimulatory CAR Improves TCR-based Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-21-0307
Abstract: This proof-of-concept study demonstrates that TCR-based therapies can be improved with engineered T cells expressing a costimulatory chimeric antigen receptor (CoCAR). CoCAR+ T cells are able to kill TCR targets, while sparing normal cells expressing… read more here.
Keywords: improves tcr; costimulatory car; car improves; costimulatory ... See more keywords
A novel diagnostic model for predicting immune microenvironment subclass based on costimulatory molecules in lung squamous carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1078790
Abstract: There is still no ideal predictive biomarker for immunotherapy response among patients with non-small cell lung cancer. Costimulatory molecules play a role in anti-tumor immune response. Hence, they can be a potential biomarker for immunotherapy… read more here.
Keywords: microenvironment; squamous carcinoma; molecules lung; costimulatory ... See more keywords
Identification of Costimulatory Molecule–Related lncRNAs Associated With Gastric Carcinoma Progression: Evidence From Bioinformatics Analysis and Cell Experiments
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.950222
Abstract: Costimulatory molecules (CMGs) play essential roles in multiple cancers. However, lncRNAs regulating costimulatory molecules have not been fully explored in gastric cancer (GC). Public data of GC patients were obtained from The Cancer Genome Atlas… read more here.
Keywords: cell; costimulatory; analysis; risk ... See more keywords
ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00502
Abstract: Phosphatidylinositol 4,5-biphosphate (PIP2) is a membrane phospholipid that controls the activity of several proteins regulating cytoskeleton reorganization, cytokine gene expression, T cell survival, proliferation, and differentiation. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are the main enzymes involved… read more here.
Keywords: phosphatidylinositol phosphate; costimulatory; isa 2011b; pro inflammatory ... See more keywords
A Signature Based on Costimulatory Molecules for the Assessment of Prognosis and Immune Characteristics in Patients With Stomach Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.928742
Abstract: Although costimulatory molecules have been shown to boost antitumor immune responses, their significance in stomach adenocarcinoma (STAD) remains unknown. The purpose of this study was to examine the gene expression patterns of costimulatory molecule genes… read more here.
Keywords: prognosis; signature; stomach adenocarcinoma; costimulatory ... See more keywords
Activation of OX40 and CD27 Costimulatory Signalling in Sheep through Recombinant Ovine Ligands
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DOI: 10.3390/vaccines8020333
Abstract: Members of the tumour necrosis factor (TNF) superfamily OX40L and CD70 and their receptors are costimulating signalling axes critical for adequate T cell activation in humans and mice but characterisation of these molecules in other… read more here.
Keywords: signalling axes; ovine ligands; costimulatory; ovine ... See more keywords