Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031667
Abstract: Accumulating evidence supports the active involvement of vascular inflammation in atherosclerosis pathogenesis. Vascular inflammatory events within atherosclerotic plaques are predominated by innate antigen-presenting cells (APCs), including dendritic cells, macrophages, and adaptive immune cells such as… read more here.
Keywords: atherosclerosis review; cd28 family; family; costimulatory coinhibitory ... See more keywords
Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026618666180531092503
Abstract: Protein-Protein Interactions (PPIs) that are part of the costimulatory and coinhibitory (immune checkpoint) signaling are critical for adequate T cell response and are important therapeutic targets for immunomodulation. Biologics targeting them have already achieved considerable… read more here.
Keywords: protein; progress; protein interactions; chemistry ... See more keywords
PRRSV-1 induced lung lesion is associated with an imbalance between costimulatory and coinhibitory immune checkpoints
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1007523
Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) induces a dysregulation on the innate and adaptive immune responses. T-cell activation requires a proper interaction and precise balance between costimulatory and coinhibitory molecules, commonly known as immune… read more here.
Keywords: coinhibitory immune; prrsv; coinhibitory; immune checkpoints ... See more keywords