Costunolide enhances sensitivity of K562/ADR chronic myeloid leukemia cells to doxorubicin through PI3K/Akt pathway
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DOI: 10.1002/ptr.6355
Abstract: Costunolide, a sesquiterpene lactone, a small molecular monomer extracted from Inula helenium, has been reported to possess antiproliferative effects on several cancer cell lines. The current study was designed to evaluate the effect of costunolide… read more here.
Keywords: adr chronic; k562 adr; costunolide; chronic myeloid ... See more keywords
Costunolide ameliorates lipoteichoic acid‐induced acute lung injury via attenuating MAPK signaling pathway
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DOI: 10.1016/j.intimp.2018.06.017
Abstract: &NA; Lipoteichoic acid (LTA)‐induced acute lung injury (ALI) is an experimental model for mimicking Gram‐positive bacteria‐induced pneumonia that is a refractory disease with lack of effective medicines. Here, we reported that costunolide, a sesquiterpene lactone,… read more here.
Keywords: lipoteichoic acid; lta induced; costunolide; signaling pathway ... See more keywords
Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-κB, STAT1/3, and Akt signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106567
Abstract: Costunolide (CTL) is the major sesquiterpene lactone from Radix Aucklandiae, which is widely used on the treatment of gastrointestinal diseases. However, the therapeutic effect of costunolide in ulcerative colitis (UC) is still unknown. Herein, we… read more here.
Keywords: dextran sulfate; sulfate sodium; costunolide; stat1 akt ... See more keywords
Costunolide induces apoptosis and inhibits migration and invasion in H1299 lung cancer cells
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DOI: 10.3892/or.2020.7566
Abstract: Costunolide being a sesquiterpene lactone, is known to have anticancer properties. The present study investigated the anticancer effects of costunolide against the H1299 human non-small-cell lung cancer (NSCLC) cell line. Inhibition of cell viability by… read more here.
Keywords: costunolide; cell; migration invasion; lung cancer ... See more keywords