Cotargeting AR signaling and cell cycle: A randomized phase II study of androgen deprivation therapy with or without palbociclib in RB-positive metastatic hormone sensitive prostate cancer (mHSPC).
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DOI: 10.1200/jco.2018.36.6_suppl.251
Abstract: 251Background: Palbociclib, a CDK4/6 inhibitor, blocked proliferation and promoted G1 arrest in an Rb and Cyclin D dependent manner in preclinical models of HSPC. Alterations in this pathway contribute to the development of CRPC. We… read more here.
Keywords: cell cycle; signaling cell; cotargeting signaling; therapy ... See more keywords