COTI-2 induces cell apoptosis in pediatric acute lymphoblastic leukemia via upregulation of miR-203
Sign Up to like & getrecommendations! Published in 2020 at "Bioengineered"
DOI: 10.1080/21655979.2020.1729927
Abstract: ABSTRACT COTI-2 is a third-generation thiosemicarbazone, which is effective against a diverse group of human cancer cell lines at nanomolar concentrations. COTI-2 also showed superior activity against tumor cells, in vitro and in vivo. As… read more here.
Keywords: coti; cell apoptosis; mir 203; jurkat cells ... See more keywords
Novel anti-cancer drug COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines
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DOI: 10.1371/journal.pone.0191766
Abstract: Emerging drug-resistance and drug-associated toxicities are two major factors limiting successful cancer therapy. Combinations of chemotherapeutic drugs have been used in the clinic to improve patient outcome. However, cancer cells can acquire resistance to drugs,… read more here.
Keywords: cross resistance; coti; drug; exhibit cross ... See more keywords
Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance
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DOI: 10.3390/cancers14184455
Abstract: Simple Summary Besides zinc, also iron and copper need to be considered to play a role in the mode of action and resistance development of the anticancer thiosemicarbazone COTI-2 and its derivatives. One of these… read more here.
Keywords: copper; besides zinc; resistance; coti ... See more keywords
Therapeutic Targeting of P53: A Comparative Analysis of APR-246 and COTI-2 in Human Tumor Primary Culture 3-D Explants
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DOI: 10.3390/genes14030747
Abstract: Background: TP53 is the most commonly mutated gene in human cancer with loss of function mutations largely concentrated in “hotspots” affecting DNA binding. APR-246 and COTI-2 are small molecules under investigation in P53 mutated cancers.… read more here.
Keywords: apr 246; activity; p53; 246 coti ... See more keywords