The structure of Na+-K+-Cl− cotransporter 1
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-019-0204-x
Abstract: A recent study reports the first high-resolution, cryo-electron microscopy-based structure of zebrafish Na+-K+-Cl− cotransporter 1 (NKCC1). This structure provides important insights into the determinants of ion translocation by NKCC1 and other cation-Cl− cotransporters such as… read more here.
Keywords: nephrology; microscopy; structure cotransporter; cotransporter ... See more keywords
Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27995-w
Abstract: The Na+–K+–2Cl− cotransporter NKCC1 plays a role in neuronal Cl− homeostasis secretion and represents a target for brain pathologies with altered NKCC1 function. Two main variants of NKCC1 have been identified: a full-length NKCC1 transcript… read more here.
Keywords: loop diuretics; cotransporter; potent bumetanide; azosemide potent ... See more keywords
Cardiorenai protective effects of sodium-glucose cotransporter 2 inhibition in combination with angiotensin II type 1 receptor blockade in salt-sensitive Dahl rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003099
Abstract: Objective: The kidney plays a central role in regulating the salt sensitivity of blood pressure (BP) by governing sodium excretion and reabsorption via renal sodium transporters. We hypothesized that sodium-glucose cotransporter 2 (SGLT2) inhibition and… read more here.
Keywords: angiotensin; inhibition; combination; cotransporter ... See more keywords
Unique regulation of Na‐glutamine cotransporter SN2/SNAT5 in rabbit intestinal crypt cells during chronic enteritis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13257
Abstract: The only Na‐nutrient cotransporter described in mammalian small intestinal crypt cells is SN2/SNAT5, which facilitates glutamine uptake. In a rabbit model of chronic intestinal inflammation, SN2 stimulation is secondary to an increase in affinity of… read more here.
Keywords: sn2; stimulation; crypt cells; cotransporter ... See more keywords
Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris
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DOI: 10.1371/journal.pone.0179968
Abstract: Cation Chloride Cotransporters (CCCs) comprise secondary active membrane proteins mainly mediating the symport of cations (Na+, K+) coupled with chloride (Cl−). They are divided into K+-Cl− outward transporters (KCCs), the Na+-K+-Cl− (NKCCs) and Na+-Cl− (NCCs)… read more here.
Keywords: cation chloride; cotransporter; hydra vulgaris; chloride cotransporter ... See more keywords
The serine-threonine protein phosphatases that regulate the thiazide-sensitive NaCl cotransporter
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1100522
Abstract: The activity of the Na+-Cl- cotransporter (NCC) in the distal convoluted tubule (DCT) is finely tuned by phosphorylation networks involving serine/threonine kinases and phosphatases. While much attention has been paid to the With-No-lysine (K) kinase… read more here.
Keywords: phosphatase; kinase; cotransporter; serine threonine ... See more keywords