Association of Sodium-Glucose Cotransporter 2 Inhibitors With Cardiovascular Outcomes in Patients With Type 2 Diabetes and Other Risk Factors for Cardiovascular Disease
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.42078
Abstract: Key Points Question What is the updated magnitude of benefit associated with sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) on outcome of cardiovascular death or hospitalization for heart failure (HHF) in different select subgroups of patients? Findings… read more here.
Keywords: cotransporter inhibitors; risk; sodium glucose; glucose cotransporter ... See more keywords
Association of Sodium-Glucose Cotransporter-2 Inhibitors With Incident Atrial Fibrillation in Older Adults With Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.35995
Abstract: Key Points Question Is use of sodium-glucose cotransporter-2 inhibitors (SGLT-2is) associated with reduced risk of atrial fibrillation (AF) in older patients with type 2 diabetes? Findings In this US nationwide cohort study assessing the risk… read more here.
Keywords: fibrillation older; glucose cotransporter; type diabetes; cotransporter inhibitors ... See more keywords
New insights into cellular links between sodium–glucose cotransporter‐2 inhibitors and ketogenesis
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DOI: 10.1002/jcb.30327
Abstract: Sodium–glucose cotransporter‐2 inhibitors (SGLT2is) are a newly developed class of highly effective antidiabetic therapies that normalize hyperglycemia via urinary glucose excretion. However, they may be accompanied by certain side effects that negatively impact their therapeutic… read more here.
Keywords: glucose cotransporter; insights cellular; cotransporter inhibitors; sodium glucose ... See more keywords
Sodium–Glucose Cotransporter 2 Inhibitors and Major COVID-19 Outcomes: Promising Mechanisms, Conflicting Data, and Intriguing Clinical Decisions
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes Therapy"
DOI: 10.1007/s13300-020-00942-7
Abstract: Dear Editor, In their anecdotal report, Bossi and colleagues demonstrate that ‘‘off-label’’ use of sodium–glucose cotransporter 2 (SGLT2) inhibitors in three subjects with severe or critical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia without… read more here.
Keywords: sodium glucose; cotransporter inhibitors; covid; inhibitors major ... See more keywords
Sodium-Glucose Cotransporter Inhibitors as Antidiabetic Drugs: Current Development and Future Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00867
Abstract: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors (gliflozins) represent the most recently approved class of oral antidiabetic drugs. SGLT-2 overexpression in diabetic patients contributes significantly to hyperglycemia and related complications. Therefore, SGLT-2 became a highly interesting therapeutic… read more here.
Keywords: antidiabetic drugs; sglt; glucose cotransporter; cotransporter inhibitors ... See more keywords
Postcardiac Surgery Euglycemic Diabetic Ketoacidosis in Patients on Sodium-Glucose Cotransporter 2 Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2023.01.041
Abstract: OBJECTIVES To evaluate sodium-glucose cotransporter 2 inhibitors (SGLT2i) use and complications (euglycemic diabetic ketoacidosis [eDKA] rate, mortality, infection, hospital, and cardiovascular intensive care unit [CVICU] length of stay [LOS]) in patients undergoing cardiac surgery. DESIGN… read more here.
Keywords: surgery; glucose cotransporter; cardiac surgery; sglt2i use ... See more keywords
Sodium-glucose cotransporter 2 inhibitors vs. sitagliptin in heart failure and type 2 diabetes: an observational cohort study.
Sign Up to like & getrecommendations! Published in 2023 at "European heart journal"
DOI: 10.1093/eurheartj/ehad273
Abstract: AIMS The effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with heart failure (HF) in routine clinical practice is not extensively studied. This study aimed to evaluate the comparative effectiveness of SGLT2i vs. sitagliptin… read more here.
Keywords: heart failure; glucose cotransporter; type diabetes; heart ... See more keywords
MO652EFFECT OF ESTIMATED GLOMERULAR FILTRATION RATE (EGFR) ON HEMOGLOBIN CHANGE INDUCED BY SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITORS (SGLT2I)
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab094.0020
Abstract: The use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) is associated with increase of hemoglobin (Hb) levels and this effect has been related to improvement of tubulointerstitial hypoxia and increase on EPO production. Chronic kidney disease… read more here.
Keywords: cotransporter inhibitors; estimated glomerular; sodium glucose; increase ... See more keywords
Sodium-glucose cotransporter 2 inhibitors at the intersection of cardiovascular, renal and metabolic care: an integrated and multidisciplinary approach to patient-centered care.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Cardiology"
DOI: 10.1097/hco.0000000000000774
Abstract: PURPOSE OF REVIEW The management of individuals who live with type 2 diabetes requires an integrated and multifaceted approach. RECENT FINDINGS Sodium-glucose cotransporter 2 inhibitors effectively prevent and treat cardiorenal complications in the presence of… read more here.
Keywords: care; cotransporter inhibitors; renal metabolic; sodium glucose ... See more keywords
Sodium‐glucose cotransporter 2 inhibitors for treatment of diabetes mellitus after kidney transplantation
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DOI: 10.1111/ctr.14718
Abstract: Diabetes mellitus in kidney transplant recipients is a risk factor for cardiovascular events and premature death. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) are increasingly used in nontransplant populations to improve diabetes control and cardiovascular and renal… read more here.
Keywords: mellitus kidney; glucose cotransporter; diabetes mellitus; cotransporter inhibitors ... See more keywords
Effects of sodium‐glucose cotransporter inhibitors on cardiorenal and metabolic systems: Latest perspectives from the outcome trials
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DOI: 10.1111/dom.13696
Abstract: Diabetes mellitus is strongly linked to high risk of cardiovascular and renal disorders. Diabetes management requires coordinated efforts to manage multiple cardiometabolic risk factors. Diabetes mellitus is also associated with poor outcome in patients after… read more here.
Keywords: sodium glucose; effects sodium; cotransporter inhibitors; cardiorenal metabolic ... See more keywords