The persistence of chronic opioid use in patients with inflammatory bowel disease-A nationwide cohort study.
Sign Up to like & getrecommendations! Published in 2025 at "British journal of clinical pharmacology"
DOI: 10.1002/bcp.70316
Abstract: AIMS Pain is common in patients with Crohn's disease (CD) and ulcerative colitis (UC), and a substantial proportion develop chronic opioid use (COU). We examined the persistence of COU over time and identified factors predicting… read more here.
Keywords: year; opioid use; persistent cou; cou ... See more keywords
IND-enabling preclinical studies of [11C]COU, a trapped metabolite PET radiotracer for monoamine oxidase-B
Sign Up to like & getrecommendations! Published in 2025 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-025-03496-0
Abstract: [11C]COU is a trapped metabolite radiotracer for in vivo analysis of Monoamine Oxidase B activity using positron emission tomography (PET) imaging. [11C]COU has the potential to quantify astrocytosis in the early stages of Alzheimer’s disease,… read more here.
Keywords: trapped metabolite; cou trapped; preclinical studies; 11c cou ... See more keywords
Risk of Chronic Opioid Use After Radiation for Head and Neck Cancer: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Radiation Oncology"
DOI: 10.1016/j.adro.2020.09.023
Abstract: Purpose Opioid addiction is a major public health concern. Chronic opioid use (COU) patterns after radiation for head and neck cancer (HNC) remain poorly understood. The aim of this study was to estimate the prevalence… read more here.
Keywords: risk; opioid use; radiation; cou ... See more keywords
Chronic opioid use is associated with increased postoperative urinary retention, length of stay and non-routine discharge following lumbar fusion surgery
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2020.106161
Abstract: BACKGROUND The incidence of chronic opioid use (COU) is increasing with health related complications impacting both patients and healthcare services. OBJECTIVE The aim of this study was to identify the impact of COU on postoperative… read more here.
Keywords: postoperative urinary; opioid use; cou; lumbar fusion ... See more keywords
Transport mechanism of chitosan‐N‐acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan decorated coumarin‐6 loaded nanostructured lipid carriers across the rabbit ocular
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.08.013
Abstract: ABSTRACT To facilitate the hydrophobic drugs modeled by coumarin‐6 (Cou‐6) acrossing the cornea to the anterior chamber of the rabbit eye, chitosan (CS) derivatives including chitosan‐N‐acetyl‐l‐cysteine (CS‐NAC), chitosan oligosaccharides (COS) and carboxymethyl chitosan (CMCS) modified… read more here.
Keywords: lipid carriers; carboxymethyl chitosan; chitosan; chitosan oligosaccharides ... See more keywords
Syndrome d’apnées obstructives du sommeil et type d’obésité
Sign Up to like & getrecommendations! Published in 2017 at "Revue Des Maladies Respiratoires"
DOI: 10.1016/j.rmr.2016.10.695
Abstract: Introduction Le type d’obesite joue un role important dans la relation entre SAOS et obesite. L’obesite abdominale est definie par un tour de taille > 90 cm chez la femme et > 100 cm chez l’homme. Le risque d’apnee est… read more here.
Keywords: dans des; cas; des cas; cou ... See more keywords
Relationship between patient-reported outcomes and clinical outcomes in metastatic castration-resistant prostate cancer: post hoc analysis of COU-AA-301 and COU-AA-302
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx759
Abstract: Background Patient-reported outcomes (PROs) are used to assess benefit-risk in drug development. The relationship between PROs and clinical outcomes is not well understood. We aim to elucidate the relationships between changes in PRO measures and… read more here.
Keywords: clinical outcomes; prostate cancer; cou 302; cou ... See more keywords
Furin-Triggered Peptide Self-Assembly Activates Coumarin Excimer Fluorescence for Precision Live-Cell Imaging
Sign Up to like & getrecommendations! Published in 2025 at "Molecules"
DOI: 10.3390/molecules30112465
Abstract: Monomer-to-excimer transition has become a valuable technique in fluorescence imaging because of its ability to enhance imaging contrast. However, from a practical perspective, the accuracy of excimer formation at target sites warrants further exploration. Enzyme-triggered… read more here.
Keywords: fluorescence; triggered peptide; peptide self; cell imaging ... See more keywords
The Ameliorative Effect of Coumarin on Copper Toxicity in Citrus sinensis: Insights from Growth, Nutrient Uptake, Oxidative Damage, and Photosynthetic Performance
Sign Up to like & getrecommendations! Published in 2024 at "Plants"
DOI: 10.3390/plants13243584
Abstract: Excessive copper (Cu) has become a common physiological disorder restricting the sustainable production of citrus. Coumarin (COU) is a hydroxycinnamic acid that can protect plants from heavy metal toxicity. No data to date are available… read more here.
Keywords: ameliorative effect; citrus; damage; toxicity ... See more keywords