Synthesis and biological evaluation of new coumarin derivatives as cytotoxic agents
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100029
Abstract: New coumarin derivatives 9a–f, 10a–e, and 11a–f were synthesized and evaluated for their cytotoxic activity against a human breast cancer cell line (MCF‐7). All compounds exhibited good activity in the nanomolar range, using doxorubicin and… read more here.
Keywords: new coumarin; biological evaluation; evaluation new; coumarin derivatives ... See more keywords
Membrane‐Permeant, Bioactivatable Coumarin Derivatives for In‐Cell Labelling
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DOI: 10.1002/cbic.202100699
Abstract: The delivery of small molecule fluorophores with minimal compartmentalization is currently one of the most critical technical problems in intracellular labelling. Here we introduce sulfonated and phosphonated coumarin dyes, demonstrate rapid cell entry via a… read more here.
Keywords: derivatives cell; membrane permeant; cell labelling; coumarin derivatives ... See more keywords
An Efficient One-Pot Synthesis of New Coumarin Derivatives as Potent Anticancer Agents under Microwave Irradiation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2975
Abstract: An efficient and rapid synthesis of coumarin derivatives was accomplished via reactions of 3-(3-(4-methoxyphenyl)acryloyl)-2H-chromen-2-one (3) with different carbon nucleophiles such as ethyl acetoacetate, ethyl cyanoacetate, malononitrile, and ethyl benzoylacetate via conventional heating and microwave irradiation… read more here.
Keywords: microwave irradiation; coumarin; efficient one; coumarin derivatives ... See more keywords
Metal ions doped into merocyanine form of coumarin derivatives: nonlinear optical molecular switches
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4068-6
Abstract: In the present study, DFT calculations are carried out on domestically designed 7-methyl-2-phenyl-5’H-spiro[chromene-4,2′-chromeno[3,4-e][1,3]oxazin]-5′-one spiropyran and merocyanine derivatives to recognize alkali and alkaline earth metal ions. Detection of these metal ions can be attained by exploiting… read more here.
Keywords: first hyperpolarizability; metal ions; metal; coumarin derivatives ... See more keywords
Metal-catalyzed synthetic strategies toward coumarin derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-018-2262-6
Abstract: Modern approaches toward coumarin ring construction based on metal-catalyzed reactions significantly complement and extend the applicability of classical methods by increasing the reaction rates and product yields. The present review summarizes various approaches to the… read more here.
Keywords: catalyzed synthetic; toward coumarin; metal catalyzed; coumarin derivatives ... See more keywords
Fluorescent probes on the basis of coumarin derivatives for determining biogenic thiols and thiophenols
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02486-6
Abstract: In this minireview, we consider the reactivity of fluorescent probes on the basis of coumarin derivatives for the purpose of detecting biogenic thiols (cysteine, homocysteine, glutathione) and thiophenols. References are provided to literature sources from… read more here.
Keywords: probes basis; basis coumarin; coumarin derivatives; fluorescent probes ... See more keywords
Substituent Effect on AIE mechanism of two coumarin derivatives: uncommon TICT fluorescence in aggregation state.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of fluorescence"
DOI: 10.1007/s10895-022-02933-2
Abstract: Two coumarin derivatives, 7-diethylamino-3-(4-nitrophenyl)coumarin (DNC) and 7-hydroxy-3-(4-nitrophenyl)coumarin (HNC), were synthesized via Knoevenagel condensation of salicylaldehyde derivatives with 4-nitrophenylacetonitrile and then cyclization reaction. Both of them were characterized by single-crystal X-ray diffraction. The molecules of DNC… read more here.
Keywords: aie; two coumarin; coumarin; fluorescence ... See more keywords
Study of Fluorescence Quenching on Novel Coumarin Derivatives by Aniline in Different Solvents
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DOI: 10.1007/s10953-017-0645-4
Abstract: The steady-state fluorescence quenching of novel coumarin derivatives; 4-(2, 6-dibromo-4-methyl-phenoxymethyl)-benzo[h]chromen-2-one [DMB] and 6-methoxy-4-p-tolyoxymethyl-chromen-2-one [TMC] has been studied in toluene, benzene, dioxane, acetonitrile and tetrahydrofuran [THF] using aniline as a quencher at room temperature with a… read more here.
Keywords: fluorescence quenching; novel coumarin; fluorescence; quenching novel ... See more keywords
Evaluation on antiviral activity of coumarin derivatives against spring viraemia of carp virus in epithelioma papulosum cyprini cells
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DOI: 10.1016/j.antiviral.2017.06.007
Abstract: Abstract As one of the most serious pathogens in the freshwater aquatic environment, spring viraemia of carp virus (SVCV) induces a high mortality rate in several cyprinid fishes. In this study, we designed and synthesized… read more here.
Keywords: carp virus; viraemia carp; spring viraemia; coumarin derivatives ... See more keywords
A novel reactive chemosensor for sulfide detection with high selectivity and sensitivity based on 4-Cl coumarin derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2021.109373
Abstract: Abstract We describe the design and synthesis of a novel reactive chemosensor based on 4-Cl Coumarin derivatives. This chemosensor displays significantly fluorescence performance in the detection of sulfur ions in water samples, and the inactive… read more here.
Keywords: coumarin derivatives; novel reactive; reactive chemosensor; based coumarin ... See more keywords
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.020
Abstract: A small library of coumarins, carrying butynyl-amino chains, was synthesized continuing our studies in the field of MDR reverting ageEnts and in order to obtain multipotent agents to combat malignancies. In particular, the reported anticancer… read more here.
Keywords: derivatives potential; coumarin; coumarin derivatives; antitumor ... See more keywords