Novel nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors: design, synthesis, in vitro and in silico studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-02018-6
Abstract: Abstract Alzheimer’s disease is a degenerative brain condition that is the leading cause of dementia affecting millions of people around the world. Therapeutic development has focused on the problem of the loss of basal forebrain… read more here.
Keywords: nicotinonitrile coumarin; hybrids potential; acetylcholinesterase inhibitors; coumarin hybrids ... See more keywords
Design and Synthesis of Novel Vitamin D–Coumarin Hybrids using Microwave Irradiation
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DOI: 10.3184/174751917x15121208772534
Abstract: A series of novel vitamin D–coumarin hybrids were synthesised by esterification of the corresponding coumarin-3-carboxylic acids and vitamin D or vitamin D CD-ring alcohol in CH2Cl2 under microwave irradiation. They were obtained in higher yields… read more here.
Keywords: novel vitamin; microwave irradiation; vitamin coumarin; coumarin hybrids ... See more keywords
Novel Nitric Oxide Donor Dinitroazetidine-Coumarin Hybrids as Potent Anti-Intrahepatic Cholangiocarcinoma Agents
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DOI: 10.3390/molecules27134021
Abstract: Intrahepatic cholangiocarcinoma (iCC) is a serious liver cancer threatening human health. However, there are a few chemotherapeutic drugs for the treatment of iCC in the clinic. It is extremely urgent to develop new drugs for… read more here.
Keywords: cell; intrahepatic cholangiocarcinoma; coumarin hybrids; dinitroazetidine coumarin ... See more keywords
The Synthesis and Biological Evaluation of Aloe-Emodin-Coumarin Hybrids as Potential Antitumor Agents
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DOI: 10.3390/molecules27196153
Abstract: A series of novel aloe-emodin–coumarin hybrids were designed and synthesized. The antitumor activity of these derivatives was evaluated against five human tumor cell lines (A549, SGC-7901, HepG2, MCF-7 and HCT-8). Some of the synthesized compounds… read more here.
Keywords: emodin coumarin; antitumor; aloe emodin; coumarin hybrids ... See more keywords