Synthesis, characterization, molecular docking, and biological activities of coumarin–1,2,3‐triazole‐acetamide hybrid derivatives
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DOI: 10.1002/ardp.202000109
Abstract: Coumarins and their derivatives are receiving increasing attention due to numerous biochemical and pharmacological applications. In this study, a series of novel coumarin–1,2,3‐triazole‐acetamide hybrids was tested against some metabolic enzymes including α‐glycosidase (α‐Gly), α‐amylase (α‐Amy),… read more here.
Keywords: coumarin triazole; triazole acetamide; acetamide hybrids; metabolic enzymes ... See more keywords
Trifluoromethyl group containing C3 symmetric coumarin-triazole based fluorometric tripodal receptors for selective fluoride ion recognition: A theoretical and experimental approach
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DOI: 10.1016/j.jfluchem.2018.06.005
Abstract: Abstract A series of unique C3 symmetric tripodal receptors, A–E containing hexasubstituted aryl core decorated with an alternate array of coumarin-triazole moieties and methyl groups have been synthesized, characterized and investigated for fluoride ion recognition… read more here.
Keywords: coumarin triazole; fluoride ion; ion; ion recognition ... See more keywords
Synthesis and Biological Evaluation of Coumarin Triazoles as Dual Inhibitors of Cholinesterases and β-Secretase
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DOI: 10.1021/acsomega.2c07993
Abstract: Coumarin is a naturally occurring bioactive pharmacophore with wide occurrence among central nervous system (CNS)-active small molecules. 8-Acetylcoumarin, one of the natural coumarins, is a mild inhibitor of cholinesterases and β-secretase, which are vital targets… read more here.
Keywords: synthesis biological; biological evaluation; coumarin; triazole hybrids ... See more keywords
Coumarin-1,2,3-triazole hybrid derivatives: Green synthesis and DFT calculations
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DOI: 10.1080/00397911.2018.1557686
Abstract: Abstract A series of new 1,2,3-triazole-coumarin hybrid system are synthesized from the click reaction between 3-azido coumarin and different aromatic terminal alkyne derivatives in a green manner. All compounds are characterized by IR, NMR and… read more here.
Keywords: coumarin triazole; derivatives green; green synthesis; hybrid derivatives ... See more keywords
QSAR and Molecular Docking Studies of Pyrimidine-Coumarin-Triazole Conjugates as Prospective Anti-Breast Cancer Agents
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DOI: 10.3390/molecules27061845
Abstract: Cancer is a life-threatening disease and is the second leading cause of death worldwide. Although many drugs are available for the treatment of cancer, survival outcomes are very low. Hence, rapid development of newer anticancer… read more here.
Keywords: pyrimidine coumarin; breast cancer; triazole conjugates; coumarin triazole ... See more keywords