Selecting Counterions to Improve Ionized Hydrophilic Drug Encapsulation in Polymeric Nanoparticles.
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DOI: 10.1021/acs.molpharmaceut.2c00855
Abstract: Hydrophobic ion pairing (HIP) can successfully increase the drug loading and control the release kinetics of ionizable hydrophilic drugs, addressing challenges that prevent these molecules from reaching the clinic. Nevertheless, polymeric nanoparticle (PNP) formulation development… read more here.
Keywords: pamoic acid; counterions improve; hydrophilic drug; drug ... See more keywords