Dosage Counts: Correcting Trisomy-21-Related Phenotypes in Human Organoids and Xenografts.
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DOI: 10.1016/j.stem.2019.05.009
Abstract: Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse… read more here.
Keywords: trisomy related; correcting trisomy; related phenotypes; dosage counts ... See more keywords