Orphan nuclear receptor COUP-TFII is an oncogenic gene in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-019-02190-z
Abstract: Background Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) may be an oncogenic gene in renal cell carcinoma (RCC). However, the direct association between COUP-TFII expression and patient survival has not been investigated in patients with… read more here.
Keywords: coup; cell; coup tfii; oncogenic gene ... See more keywords
COUP-TFII revisited: Its role in metabolic gene regulation
Sign Up to like & getrecommendations! Published in 2019 at "Steroids"
DOI: 10.1016/j.steroids.2018.11.013
Abstract: &NA; Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP‐TFII) is an orphan member of the nuclear receptor family of transcriptional regulators. Although hormonal activation of COUP‐TFII has not yet been identified, rodent genetic models have… read more here.
Keywords: coup; metabolic gene; gene regulation; coup tfii ... See more keywords
Augmented angiogenic transcription factor, SOX18, is associated with asthma exacerbation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Asthma"
DOI: 10.1080/02770903.2020.1771727
Abstract: Abstract Background Asthma characterized by airway hyperresponsiveness, inflammation, fibrosis, and angiogenesis. SRY-related HMG-box 18 (SOX18) is an important transcription factor involved in angiogenesis, tissue injury, wound-healing, and in embryonic cardiovascular and lymphatic vessels development. The… read more here.
Keywords: transcription; coup tfii; sox18; transcription factor ... See more keywords
COUP-TFII promotes metastasis and epithelial-to-mesenchymal transition through upregulating Snail in human intrahepatic cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmaa117
Abstract: Intrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. The overexpression of COUP-TFII has been observed in several types of malignancies. However, its… read more here.
Keywords: mesenchymal transition; coup tfii; coup; epithelial mesenchymal ... See more keywords
The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-00266
Abstract: Abstract The nuclear receptor chicken ovalbumin upstream promoter–transcription factor type II (COUP-TFII)/NR2F2 is expressed in adult Leydig cells, and conditional deletion of the Coup-tfii/Nr2f2 gene impedes their differentiation. Steroid production is also reduced in COUP-TFII–depleted… read more here.
Keywords: coup; amhr2 promoter; leydig cells; coup tfii ... See more keywords
SAT-560 Role of COUP-TFII and Thyroid Hormone Receptor α in Skeletal Muscle Loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-560
Abstract: Abstract Myopathic changes including muscular dystrophy and weakness are commonly described in hypothyroid and hyperthyroid patients. The genomic actions of triiodothyronine (T3) are mediated by thyroid hormone nuclear receptors (TRs), which act as ligand-inducible transcription… read more here.
Keywords: skeletal muscle; muscle; coup tfii; loss ... See more keywords
COUP-TFII in Kidneys, from Embryos to Sick Adults
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12051181
Abstract: Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is an orphan nuclear hormone receptor of unknown ligands. This molecule has two interesting features: (1) it is a developmental gene, and (2) it is a potential hormone… read more here.
Keywords: coup tfii; tfii kidneys; sick adults; embryos sick ... See more keywords
COUP‑TFII promotes epithelial‑mesenchymal transition by inhibiting miR‑34a expression in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of oncology"
DOI: 10.3892/ijo.2019.4718
Abstract: Chicken ovalbumin upstream promoter‑transcription factor II (COUP‑TFII) expression is upregulated in colorectal cancer and is associated with its progression and a poor prognosis. The aim of the present study was to determine whether COUP‑TFII regulates colorectal… read more here.
Keywords: expression; migration; coup tfii; mir 34a ... See more keywords
Isoforms of the orphan nuclear receptor COUP‑TFII differentially modulate pancreatic cancer progression.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of oncology"
DOI: 10.3892/ijo.2022.5345
Abstract: The expression of the nuclear receptor transcription factor (TF) COUP‑TFII is broadly associated with cell differentiation and cancer development, including of pancreatic ductal adenocarcinoma (PDAC), a devastating disease with one of the poorest prognoses among… read more here.
Keywords: cancer; coup; nuclear receptor; coup tfii ... See more keywords
Downregulation of COUP-TFII inhibits glioblastoma growth via targeting MPC1
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DOI: 10.3892/ol.2018.8601
Abstract: Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is a steroid receptor that is broadly expressed in many tissues throughout embryonic development. Previous studies indicated that COUP-TFII is dysregulated in multiple types of cancer and… read more here.
Keywords: downregulation coup; coup tfii; tfii inhibits; coup ... See more keywords