Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity
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DOI: 10.1021/acs.jmedchem.2c00897
Abstract: High-throughput screening provides one of the most common ways of finding hit compounds. Lead-like libraries, in particular, provide hits with compatible functional groups and vectors for structural elaboration and physical properties suitable for optimization. Library… read more here.
Keywords: lead like; couple transform; synthesis; diversity ... See more keywords