Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).
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DOI: 10.1021/acs.jmedchem.8b00308
Abstract: Bile acid signaling and metabolism in the gastrointestinal tract have wide-ranging influences on systemic disease. G protein-coupled bile acid receptor 1 (GPBAR1, TGR5) is one of the major effectors in bile acid sensing, with demonstrated… read more here.
Keywords: gut restricted; coupled bile; protein coupled; acid ... See more keywords