Downhill (Un)Folding Coupled to Binding as Mechanism for Engineering Broadband Protein Conformational Transducers.
Sign Up to like & getrecommendations! Published in 2020 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.0c00190
Abstract: Canonical proteins fold and function as conformational switches that toggle between their folded (on) and unfolded (off) states, a mechanism that also provides the basis for engineering transducers for biosensor applications. One of the limitations… read more here.
Keywords: engineering; coupled binding; folding coupled; downhill folding ... See more keywords
Effects of flexibility and electrostatic interactions on the coupled binding-folding mechanisms of Chz.core and H2A.z-H2B.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00103g
Abstract: The intrinsically disordered protein (IDP) Chz.core, which is the interaction core of Chz1, shows binding preference to histone variant H2A.z. Although there are several studies on the binding process of Chz.core, the detailed coupled binding-folding… read more here.
Keywords: flexibility; coupled binding; chz core; binding folding ... See more keywords