G protein‐coupled estrogen receptor‐1 enhances excitatory synaptic responses in the entorhinal cortex
Sign Up to like & getrecommendations! Published in 2021 at "Hippocampus"
DOI: 10.1002/hipo.23383
Abstract: Activation of estrogen receptors is thought to modulate cognitive function in the hippocampus, prefrontal cortex, and striatum by affecting both excitatory and inhibitory synaptic transmission. The entorhinal cortex is a major source of cortical sensory… read more here.
Keywords: entorhinal cortex; cortex; coupled estrogen; synaptic transmission ... See more keywords
Do G-protein coupled estrogen receptor and bisphenol A analogs influence on Leydig cell epigenetic regulation in immature boar testis ex vivo?
Sign Up to like & getrecommendations! Published in 2019 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2019.06.006
Abstract: Organotypic culture of testicular fragments from 7-day-old male pigs (Polish White Large) was used. Tissues were treated with an antagonist of G-protein coupled estrogen receptor (GPER) (G-15; 10 nM), and bisphenol A (BPA), and its analogs… read more here.
Keywords: protein; bpa; treatment; coupled estrogen ... See more keywords
Estrogen stabilizes hypoxia-inducible factor 1α through G protein-coupled estrogen receptor 1 in eutopic endometrium of endometriosis.
Sign Up to like & getrecommendations! Published in 2017 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2016.11.008
Abstract: OBJECTIVE To investigate whether G protein-coupled estrogen receptor (GPER, also known as GPR30 and GPER1) stabilizes hypoxia-inducible factor 1α (HIF-1α) in eutopic endometrium (EuEM) of endometriosis. DESIGN Immunohistochemical analysis and experimental in vitro study. SETTING University… read more here.
Keywords: protein; coupled estrogen; protein coupled; factor ... See more keywords
Activation of G protein-coupled estrogen receptor fine-tunes age-related decreased vascular activities in the aortae of female and male rats
Sign Up to like & getrecommendations! Published in 2022 at "Steroids"
DOI: 10.1016/j.steroids.2022.108997
Abstract: BACKGROUND Hormone replacement therapy was found to be effective in cardiovascular protection only in younger women, not in older women. In this study, we tested whether G protein-coupled estrogen receptor 1 (GPER) activation improves vascular… read more here.
Keywords: vascular activities; response; age; protein coupled ... See more keywords
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0631-3
Abstract: Tamoxifen has been used for many years to target estrogen receptor signalling in breast cancer cells. Tamoxifen is also an agonist of the G protein-coupled estrogen receptor (GPER), a GPCR ubiquitously expressed in tissues that… read more here.
Keywords: coupled estrogen; protein coupled; tamoxifen; receptor ... See more keywords
Abstract PR16: Specific activation of the G protein-coupled estrogen receptor inhibits melanoma and other cancers and potentiates immune and targeted therapies
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.mel2019-pr16
Abstract: Modern immune and targeted therapies appear more effective against advanced melanoma in women than in men. Melanoma incidence is also lower in women. Similar sex differences are observed in other tumors that are not classically… read more here.
Keywords: activation; protein coupled; melanoma; targeted therapies ... See more keywords
Hydroxylated Polybrominated Biphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein–Coupled Estrogen Receptor Mediated Pathways
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Health Perspectives"
DOI: 10.1289/ehp2387
Abstract: Background: Numerous studies have indicated the estrogenic effects of polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs (OH-PBDEs). However, the previous mechanistic studies focused on their estrogenic effects through genomic transcriptional activation of estrogen receptors. Objective:… read more here.
Keywords: gper pathways; coupled estrogen; protein coupled; gper ... See more keywords
Selective Activation of G protein-coupled Estrogen Receptor 1 Attenuates Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230501231528
Abstract: Atherosclerosis remains a leading contributor to cardiovascular disease-associated morbidity and mortality. Interestingly, the death rate is higher in men than women from atherosclerosis, and the risk increases for postmenopausal women. This suggested a protective role… read more here.
Keywords: estrogen receptor; coupled estrogen; atherosclerosis; selective activation ... See more keywords
Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12010099
Abstract: Simple Summary The overall goal of this study was to examine the role of G-protein-coupled estrogen receptor 1 signaling in the regulation of the early inflammatory process following global cerebral ischemia. The results of the… read more here.
Keywords: estrogen receptor; coupled estrogen; brain; cerebral ischemia ... See more keywords
Emerging Roles for G Protein-Coupled Estrogen Receptor 1 in Cardio-Renal Health: Implications for Aging
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12030412
Abstract: Cardiovascular (CV) and renal diseases are increasingly prevalent in the United States and globally. CV-related mortality is the leading cause of death in the United States, while renal-related mortality is the 8th. Despite advanced therapeutics,… read more here.
Keywords: estrogen receptor; coupled estrogen; renal health; cardio renal ... See more keywords
G-Protein-Coupled Estrogen Receptor Expression in Rat Uterine Artery Is Increased by Pregnancy and Induces Dilation in a Ca2+ and ERK1/2 Dependent Manner
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23115996
Abstract: Increasing levels of estrogens across gestation are partly responsible for the physiological adaptations of the maternal vasculature to pregnancy. The G protein-coupled estrogen receptor (GPER) mediates acute vasorelaxing effects in the uterine vasculature, which may… read more here.
Keywords: estrogen receptor; uterine arteries; coupled estrogen; expression ... See more keywords