Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds
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DOI: 10.1038/s41416-020-0912-9
Abstract: Background Expression of proton-coupled folate transporter (PCFT) is associated with survival of mesothelioma patients treated with pemetrexed, and is reduced by hypoxia, prompting studies to elucidate their correlation. Methods Modulation of glycolytic gene expression was… read more here.
Keywords: mesothelioma; coupled folate; proton coupled; ldh ... See more keywords