Overcoming the Cost of Positive Autoregulation by Accelerating the Response with a Coupled Negative Feedback
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DOI: 10.1016/j.celrep.2018.08.023
Abstract: SUMMARY A fundamental trade-off between rapid response and optimal expression of genes below cytotoxic levels exists for many signaling circuits, particularly for positively autoregulated systems with an inherent response delay. Here, we describe a regulatory… read more here.
Keywords: autoregulation; cost positive; response; feedback ... See more keywords