Pd-Catalyzed Regio- and Stereoselective Synthesis of Tertiary Enamides via a Three-Component Coupling of 2-Arylaziridines with Diazo Esters and Cyclic Ethers.
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DOI: 10.1021/acs.orglett.5c01268
Abstract: A palladium-catalyzed three-component coupling of 2-arylaziridines, α-diazo esters, and cyclic ethers, affording tertiary enamides with excellent regio- and stereoselectivity, is reported. This regioselective ring-opening of aziridines is different from the classical transition-metal/phosphine catalyzed ones. A… read more here.
Keywords: arylaziridines diazo; coupling arylaziridines; three component; diazo esters ... See more keywords