Ni-Catalyzed Reductive Coupling of Heteroaryl Bromides with Tertiary Alkyl Halides.
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DOI: 10.1021/acs.orglett.2c03598
Abstract: We disclose here a nickel-catalyzed reductive coupling of bromopyridines with tertiary alkyl bromides for the synthesis of alkylated pyridines bearing an all-carbon quaternary center. This strategy features mild conditions, broad substrate scope, and high functional… read more here.
Keywords: coupling heteroaryl; tertiary alkyl; reductive coupling; heteroaryl bromides ... See more keywords