Illuminating G-Protein-Coupling Selectivity of GPCRs
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DOI: 10.1016/j.cell.2019.04.044
Abstract: Heterotrimetic G proteins consist of four subfamilies (Gs, Gi/o, Gq/11, and G12/13) that mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding Gα C termini. G-protein-coupling profiles govern GPCR-induced cellular responses, yet receptor sequence… read more here.
Keywords: illuminating protein; protein coupling; coupling selectivity; gpcrs ... See more keywords
Variable G protein determinants of GPCR coupling selectivity
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1905993116
Abstract: Significance G protein-coupled receptors (GPCRs) regulate a wide variety of important cellular processes and are targeted by a large fraction of approved drugs. GPCRs signal by activating heterotrimeric G proteins and must couple to a… read more here.
Keywords: protein; terminus; coupling selectivity; coupled receptors ... See more keywords