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   Articles with "coupling synthesis" as a keyword



Metal‐Catalyzed Cross‐Coupling for the Synthesis of β‐Lactam Drugs and Related Chemical Probes

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recommendations! Published in 2025 at "Chemmedchem"

DOI: 10.1002/cmdc.202400960

Abstract: Antimicrobial resistance is a major public health threat, due to the emergence of new bacterial strains not responding to classical antibiotics. This review focuses on the use of transition metal cross‐coupling strategies used to access… read more here.

Keywords: metal catalyzed; coupling synthesis; lactam; cross coupling ... See more keywords

Radical C(sp3)-S Coupling for the Synthesis of α-Amino Sulfides.

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recommendations! Published in 2023 at "Organic letters"

DOI: 10.1021/acs.orglett.3c01121

Abstract: A unique transition-metal-free radical thiolation of 2-azaallyl anions has been developed. Easily accessible thiosulfonates and 2-azaallyls undergo the tandem process of single-electron transfer and radical-radical coupling to construct C(sp3)-S bonds. This robust protocol enables a… read more here.

Keywords: sp3 coupling; coupling synthesis; amino sulfides; radical sp3 ... See more keywords
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Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes.

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recommendations! Published in 2021 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.1c07851

Abstract: A nickel-catalyzed, multicomponent regio- and enantioselective coupling via sequential hydroformylation and carbonylation from readily available starting materials has been developed. This modular multicomponent hydrofunctionalization strategy enables the straightforward reductive hydrocarbonylation of a broad range of… read more here.

Keywords: coupling synthesis; multicomponent coupling; nickel catalyzed; catalyzed multicomponent ... See more keywords

Enantioconvergent Chan-Lam Coupling: Synthesis of Chiral Benzylic Amides via Cu-Catalyzed Deborylative Amidation.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.5c05884

Abstract: The Chan-Lam coupling represents one of the most effective methods for constructing C-N bonds due to its mild reaction conditions and broad functional group compatibility. However, asymmetric versions of this transformation to forge C(sp3)-N bonds… read more here.

Keywords: chan lam; coupling synthesis; chan; lam coupling ... See more keywords

Iron-catalysed reductive coupling for the synthesis of polyfluorinated compounds.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc06022a

Abstract: Herein we reported the use of Earth-abundant iron as the catalytic metal in the presence of Mn to induce difluorobromoacetates to form carbon radicals, which reacted with trifluoromethyl olefins followed by β-F elimination to generate… read more here.

Keywords: catalysed reductive; iron; reductive coupling; coupling synthesis ... See more keywords

First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls.

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recommendations! Published in 2024 at "Chemical communications"

DOI: 10.1039/d3cc05447k

Abstract: The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO2 additive is crucial for the success of the coupling. The longstanding problem of the lack… read more here.

Keywords: chan lam; coupling synthesis; atroposelective chan; synthesis ... See more keywords
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Electrochemical intramolecular N(sp2)–H/N(sp3)–H coupling for the synthesis of 1H-indazoles

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recommendations! Published in 2023 at "Green Chemistry"

DOI: 10.1039/d3gc00380a

Abstract: The electrochemical intramolecular cyclization of ketimines via N–H/N–H dehydrogenation coupling has been established for the construction of 1H-indazole scaffolds. read more here.

Keywords: synthesis indazoles; sp2 sp3; sp3 coupling; coupling synthesis ... See more keywords

Incorporation of Ir(C^N)2(N^N)-NiCl2 in a (N^N)-covalent organic framework for transcendent dual catalysis in photochemical cross-coupling synthesis

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recommendations! Published in 2024 at "Journal of Materials Chemistry A"

DOI: 10.1039/d4ta00443d

Abstract: The incorporation of Ir(C^N)2(N^N)-NiCl2 in quinoline-based (N^N)-covalent organic framework exhibits remarkable photocatalytic activities in cross-coupling synthesis. read more here.

Keywords: incorporation nicl2; coupling synthesis; cross coupling; organic framework ... See more keywords