Radical C(sp3)-S Coupling for the Synthesis of α-Amino Sulfides.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01121
Abstract: A unique transition-metal-free radical thiolation of 2-azaallyl anions has been developed. Easily accessible thiosulfonates and 2-azaallyls undergo the tandem process of single-electron transfer and radical-radical coupling to construct C(sp3)-S bonds. This robust protocol enables a… read more here.
Keywords: sp3 coupling; coupling synthesis; amino sulfides; radical sp3 ... See more keywords
Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c07851
Abstract: A nickel-catalyzed, multicomponent regio- and enantioselective coupling via sequential hydroformylation and carbonylation from readily available starting materials has been developed. This modular multicomponent hydrofunctionalization strategy enables the straightforward reductive hydrocarbonylation of a broad range of… read more here.
Keywords: coupling synthesis; multicomponent coupling; nickel catalyzed; catalyzed multicomponent ... See more keywords
Iron-catalysed reductive coupling for the synthesis of polyfluorinated compounds.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc06022a
Abstract: Herein we reported the use of Earth-abundant iron as the catalytic metal in the presence of Mn to induce difluorobromoacetates to form carbon radicals, which reacted with trifluoromethyl olefins followed by β-F elimination to generate… read more here.
Keywords: catalysed reductive; iron; reductive coupling; coupling synthesis ... See more keywords
Electrochemical intramolecular N(sp2)–H/N(sp3)–H coupling for the synthesis of 1H-indazoles
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DOI: 10.1039/d3gc00380a
Abstract: The electrochemical intramolecular cyclization of ketimines via N–H/N–H dehydrogenation coupling has been established for the construction of 1H-indazole scaffolds. read more here.
Keywords: synthesis indazoles; sp2 sp3; sp3 coupling; coupling synthesis ... See more keywords