[2 + 3] Annulative Coupling of Tetrahydroisoquinolines with Aryliodonio diazo compounds To Access 1,2,4-Triazolo[3,4-a]isoquinolines.
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DOI: 10.1021/acs.orglett.2c02442
Abstract: Base promoted one-pot annulative coupling of 1,2,3,4-tetrahydroisoquinolines (THIQs) with hypervalent iodine(III) species aryliodonio diazo compounds has been devised for the direct construction of 1,2,4-triazolo[3,4-a]isoquinoline derivatives at room temperature in open air for the first time.… read more here.
Keywords: triazolo; annulative coupling; diazo compounds; tetrahydroisoquinolines aryliodonio ... See more keywords
Metal-Free Oxidative Coupling of Tetrahydroisoquinolines and 3-Fluorooxindoles on Water
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DOI: 10.1055/s-0039-1690213
Abstract: An efficient, metal-free oxidative coupling of tetrahydroisoquinolines and 3-fluorooxindoles on water has been developed. Using aqueous tert-butyl hydroperoxide as the oxidant, Et3N as the base, and water as the sole solvent, a variety of 3-fluorooxindoles… read more here.
Keywords: tetrahydroisoquinolines fluorooxindoles; water; free oxidative; coupling tetrahydroisoquinolines ... See more keywords