Cross-Electrophile Coupling of Unactivated Alkyl Chlorides.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c04812
Abstract: Alkyl chlorides are bench-stable chemical feedstocks that remain among the most underutilized electrophile classes in transition metal catalysis. Overcoming intrinsic limitations of C(sp3)-Cl bond activation, we report the development of a novel organosilane reagent that… read more here.
Keywords: alkyl; alkyl chlorides; unactivated alkyl; cross electrophile ... See more keywords
Palladium-catalyzed cross-coupling of unactivated alkylzinc reagents with 2-bromo-3,3,3-trifluoropropene and its application in the synthesis of fluorinated amino acids.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc10212k
Abstract: A palladium-catalyzed cross-coupling of unactivated alkylzinc reagents with 2-bromo-3,3,3-trifluoropropene (BTP) has been developed, which was used as a key step to prepare a series of trifluoromethylated and difluoromethylated amino acids that are of great interest… read more here.
Keywords: amino acids; coupling unactivated; unactivated alkylzinc; palladium catalyzed ... See more keywords
Recent progress in the oxidative coupling of unactivated Csp3-H bonds with other C-H bonds.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc04802c
Abstract: The oxidative coupling between two carbon-hydrogen (C-H) bonds offers the most straightforward pathway to construct C-C bonds from hydrocarbons without pre-functionalization, exhibiting high step- and atom-economy. This article features the recent advances in the oxidative… read more here.
Keywords: coupling unactivated; csp3 bonds; unactivated csp3; csp3 ... See more keywords