Synergistic Effects of Natural Compounds Toward Inhibition of SARS-CoV-2 3CL Protease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00994
Abstract: The biggest challenge in medical management and control of the COVID-19 pandemic is the nonavailability of the treatment molecules. While vaccines and other biotherapeutic products for managing COVID-19 have reached the market, a small-molecule cure… read more here.
Keywords: cov 3cl; inhibition; 3cl protease; sars cov ... See more keywords
Testing Affordable Strategies for the Computational Study of Reactivity in Cysteine Proteases: The Case of SARS-CoV-2 3CL Protease Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.2c00294
Abstract: Cysteine proteases are an important target for the development of inhibitors that could be used as drugs to regulate the activity of these kinds of enzymes involved in many diseases, including COVID-19. For this reason,… read more here.
Keywords: cysteine proteases; 3cl protease; cov 3cl; study ... See more keywords
Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00117
Abstract: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Despite the rapid global spread of COVID-19 vaccines,… read more here.
Keywords: 3cl protease; discovery 217622; cov 3cl; inhibitor ... See more keywords
Bat coronaviruses related to SARS-CoV-2: what about their 3CL proteases (MPro)?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2062336
Abstract: Abstract Despite a huge effort by the scientific community to determine the animal reservoir of SARS-CoV-2, which led to the identification of several SARS-CoV-2-related viruses both in bats and in pangolins, the origin of SARS-CoV-2… read more here.
Keywords: related sars; cov 3cl; sars cov; bat coronaviruses ... See more keywords
Synthesis and SARS-CoV-2 3CL Protease Inhibitory Effects of Oxazolidinone Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20220033
Abstract: The 3-chymotrypsin-like protease (3CLpro) is an attractive target for the development of anti- SARS (severe acute respiratory syndrome) drugs. In this work, a series of oxazolidinone derivatives 3a-3v were synthesized and their inhibitory activities against… read more here.
Keywords: protease inhibitory; sars cov; synthesis sars; 3cl protease ... See more keywords
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26195782
Abstract: We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synthesized… read more here.
Keywords: cov 3cl; chloropyridinyl esters; cov 3clpro; 3cl protease ... See more keywords