ACE2: The Major Cell Entry Receptor for SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Lung"
DOI: 10.1007/s00408-020-00408-4
Abstract: Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus has infected more than 46 million people worldwide, killing over one million two hundred thousand. Understanding the mechanisms by which some individuals are… read more here.
Keywords: sars cov; cov ace2; receptor sars; cell entry ... See more keywords
Molecular docking suggests repurposing of brincidofovir as a potential drug targeting SARS-CoV-2 ACE2 receptor and main protease
Sign Up to like & getrecommendations! Published in 2020 at "Network Modeling and Analysis in Health Informatics and Bioinformatics"
DOI: 10.1007/s13721-020-00263-6
Abstract: Abstract The current outbreak of the highly transmittable and life-threatening severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly and posed a global health emergency. Many clinical trials are now being conducted to test… read more here.
Keywords: protease; cov ace2; ace2 receptor; sars cov ... See more keywords
A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114397119
Abstract: SignificanceIn the dynamic environment of the airways, where SARS-CoV-2 infections are initiated by binding to human host receptor ACE2, mechanical stability of the viral attachment is a crucial fitness advantage. Using single-molecule force spectroscopy techniques,… read more here.
Keywords: sars cov; assay probe; tethered ligand; ligand assay ... See more keywords
The Role of the SARS-CoV-2 S-Protein Glycosylation in the Interaction of SARS-CoV-2/ACE2 and Immunological Responses.
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DOI: 10.1089/vim.2020.0174
Abstract: The current pandemic is caused by the coronavirus disease 2019 (COVID-19), which is, in turn, induced by a novel coronavirus (SARS-CoV-2) that triggers an acute respiratory disease. In recent years, the emergence of SARS-CoV-2 is… read more here.
Keywords: cov ace2; protein glycosylation; cov protein; coronavirus ... See more keywords
SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings
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DOI: 10.3390/pathogens9070546
Abstract: The rapidly evolving coronavirus disease 2019 (COVID-19, caused by severe acute respiratory syndrome coronavirus 2- SARS-CoV-2), has greatly burdened the global healthcare system and led it into crisis in several countries. Lack of targeted therapeutics… read more here.
Keywords: hcq; cov ace2; cardiovascular complications; hydroxychloroquine cardiovascular ... See more keywords