Omicron - The new SARS-CoV-2 challenge?
Sign Up to like & getrecommendations! Published in 2022 at "Reviews in medical virology"
DOI: 10.1002/rmv.2358
Abstract: SARS-CoV-2 virus has infected nearly 300 M people worldwide and has been associated with over 6 M deaths by March 2022. Since the virus emergence in December 2019 in Wuhan, several new mutations have been described. The… read more here.
Keywords: number; new sars; omicron new; sars cov ... See more keywords
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07575-x
Abstract: The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited1. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics… read more here.
Keywords: sars cov; cov challenge; response; infection ... See more keywords
Bacillus Calmette-Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.157393
Abstract: SARS-CoV-2 has resulted in over 450 million confirmed cases since 2019. Although several vaccines have been certified by World Health Organization and are being vaccinated on a global scale, it has been reported that multiple… read more here.
Keywords: immunity; k18 hace2; sars cov; cov challenge ... See more keywords
Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.801799
Abstract: The tuberculosis vaccine, Bacille Calmette-Guerin (BCG), also affords protection against non-tuberculous diseases attributable to heterologous immune mechanisms such as trained innate immunity, activation of non-conventional T-cells, and cross-reactive adaptive immunity. Aerosol vaccine delivery can target… read more here.
Keywords: cov challenge; disease; bcg vaccination; sars cov ... See more keywords
Single MVA-SARS-2-ST/N Vaccination Rapidly Protects K18-hACE2 Mice against a Lethal SARS-CoV-2 Challenge Infection
Sign Up to like & getrecommendations! Published in 2024 at "Viruses"
DOI: 10.3390/v16030417
Abstract: The sudden emergence of SARS-CoV-2 demonstrates the need for new vaccines that rapidly protect in the case of an emergency. In this study, we developed a recombinant MVA vaccine co-expressing SARS-CoV-2 prefusion-stabilized spike protein (ST)… read more here.
Keywords: sars cov; sars vaccination; mva sars; cov challenge ... See more keywords