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   Articles with "cov entry" as a keyword



Epicatechin is a promising novel inhibitor of SARS-CoV-2 entry by disrupting interactions between angiotensin-converting enzyme type 2 and the viral receptor binding domain: A computational/simulation study

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recommendations! Published in 2021 at "Computers in Biology and Medicine"

DOI: 10.1016/j.compbiomed.2021.105155

Abstract: Angiotensin-converting enzyme 2 (ACE2) is the first target of SARS-CoV-2 and a key functional host receptor through which this virus hooks into and infects human cells. The necessity to block this receptor is one of… read more here.

Keywords: study; sars cov; cov entry; angiotensin converting ... See more keywords
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Proteases and variants: context matters for SARS-CoV-2 entry assays

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recommendations! Published in 2021 at "Current Opinion in Virology"

DOI: 10.1016/j.coviro.2021.07.004

Abstract: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), like other coronaviruses, relies on a flexible array of entry mechanisms, driven by the spike (S) protein. Entry is dependent on proteolytic priming, activation, and receptor binding; all… read more here.

Keywords: proteases variants; entry assays; variants context; cov entry ... See more keywords
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A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

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recommendations! Published in 2022 at "Slas Discovery"

DOI: 10.1016/j.slasd.2021.12.005

Abstract: Effective small molecule therapies to combat the SARS-CoV-2 infection are still lacking as the COVID-19 pandemic continues globally. High throughput screening assays are needed for lead discovery and optimization of small molecule SARS-CoV-2 inhibitors. In… read more here.

Keywords: sars cov; entry; cov entry; throughput screening ... See more keywords
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Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities

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recommendations! Published in 2020 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.0c00502

Abstract: Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological agent of “coronavirus disease 2019”, abbreviated to COVID-19, which despite… read more here.

Keywords: current future; entry current; inhibitors sars; cov entry ... See more keywords

Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products

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recommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-021-00531-5

Abstract: Dear Editor, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health issue. The spike (S) protein mutation D614G became dominant in SARS-CoV-2 during a global pandemic,… read more here.

Keywords: supplementary fig; cov entry; entry; fusion ... See more keywords

Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-60406-z

Abstract: SARS-CoV-2 entry into host cells is mediated by the spike protein, which drives membrane fusion. While cryo-EM reveals stable prefusion and postfusion conformations of the spike, the transient fusion intermediate states during the fusion process… read more here.

Keywords: sars cov; process; fusion; cryo ... See more keywords

UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation

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recommendations! Published in 2025 at "Journal of Virology"

DOI: 10.1128/jvi.00741-25

Abstract: ABSTRACT Since the outbreak of SARS-CoV-2, viral mutations have posed significant challenges in identifying therapeutic targets and developing broad-spectrum antiviral drugs. Post-translational modifications of genes involved in interferon production and signaling pathways play a crucial… read more here.

Keywords: sars cov; maturation; cov infection; cov entry ... See more keywords

HCV Infection Increases the Expression of ACE2 Receptor, Leading to Enhanced Entry of Both HCV and SARS-CoV-2 into Hepatocytes and a Coinfection State

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recommendations! Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.01150-22

Abstract: Here, we provide the first experimental evidence for the coexistence of SARS-CoV-2 infection with HCV, and the interplay between them. The study revealed a complex relationship of enhancement between the two viruses, where HCV infection… read more here.

Keywords: infection; cov entry; hcv; hcv sars ... See more keywords

Nasal expression of SARS-CoV-2 entry receptors in newborns

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recommendations! Published in 2021 at "Archives of Disease in Childhood"

DOI: 10.1136/archdischild-2020-321334

Abstract: Background SARS-CoV-2 infection is typically mild in children. Lower expression of SARS-CoV-2 entry receptors in the nasal epithelia have been described in children compared with adults. However, data from newborns are lacking. We compared nasal… read more here.

Keywords: expression; entry receptors; sars cov; cov entry ... See more keywords

Going viral in the islet: mediators of SARS-CoV-2 entry beyond ACE2.

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recommendations! Published in 2022 at "Journal of molecular endocrinology"

DOI: 10.1530/jme-21-0282

Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Following initial infection of airway epithelia, SARS-CoV-2 invades a wide range of cells in multiple organs, including pancreatic islet cells.… read more here.

Keywords: entry; viral entry; cov entry; islet ... See more keywords

Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.1080897

Abstract: Background Drug repurposing is a fast and effective way to develop drugs for an emerging disease such as COVID-19. The main challenges of effective drug repurposing are the discoveries of the right therapeutic targets and… read more here.

Keywords: inflammation; hamster model; methotrexate; cov entry ... See more keywords