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Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.105155
Abstract: Angiotensin-converting enzyme 2 (ACE2) is the first target of SARS-CoV-2 and a key functional host receptor through which this virus hooks into and infects human cells. The necessity to block this receptor is one of…
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Keywords:
study;
sars cov;
cov entry;
angiotensin converting ... See more keywords
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Published in 2021 at "Current Opinion in Virology"
DOI: 10.1016/j.coviro.2021.07.004
Abstract: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), like other coronaviruses, relies on a flexible array of entry mechanisms, driven by the spike (S) protein. Entry is dependent on proteolytic priming, activation, and receptor binding; all…
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Keywords:
proteases variants;
entry assays;
variants context;
cov entry ... See more keywords
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Published in 2022 at "Slas Discovery"
DOI: 10.1016/j.slasd.2021.12.005
Abstract: Effective small molecule therapies to combat the SARS-CoV-2 infection are still lacking as the COVID-19 pandemic continues globally. High throughput screening assays are needed for lead discovery and optimization of small molecule SARS-CoV-2 inhibitors. In…
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Keywords:
sars cov;
entry;
cov entry;
throughput screening ... See more keywords
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Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.0c00502
Abstract: Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological agent of “coronavirus disease 2019”, abbreviated to COVID-19, which despite…
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Keywords:
current future;
entry current;
inhibitors sars;
cov entry ... See more keywords
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Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00531-5
Abstract: Dear Editor, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health issue. The spike (S) protein mutation D614G became dominant in SARS-CoV-2 during a global pandemic,…
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Keywords:
supplementary fig;
cov entry;
entry;
fusion ... See more keywords
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Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01150-22
Abstract: Here, we provide the first experimental evidence for the coexistence of SARS-CoV-2 infection with HCV, and the interplay between them. The study revealed a complex relationship of enhancement between the two viruses, where HCV infection…
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Keywords:
infection;
cov entry;
hcv;
hcv sars ... See more keywords
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Published in 2021 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2020-321334
Abstract: Background SARS-CoV-2 infection is typically mild in children. Lower expression of SARS-CoV-2 entry receptors in the nasal epithelia have been described in children compared with adults. However, data from newborns are lacking. We compared nasal…
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Keywords:
expression;
entry receptors;
sars cov;
cov entry ... See more keywords
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Published in 2022 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-21-0282
Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Following initial infection of airway epithelia, SARS-CoV-2 invades a wide range of cells in multiple organs, including pancreatic islet cells.…
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Keywords:
entry;
viral entry;
cov entry;
islet ... See more keywords
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Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1080897
Abstract: Background Drug repurposing is a fast and effective way to develop drugs for an emerging disease such as COVID-19. The main challenges of effective drug repurposing are the discoveries of the right therapeutic targets and…
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Keywords:
inflammation;
hamster model;
methotrexate;
cov entry ... See more keywords
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Published in 2020 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2020.619453
Abstract: SARS-CoV-2 enters into human airway epithelial cells via membrane fusion or endocytosis, and this process is dependent on ACE2, TMPRSS2, and cathepsin L. In this study, we examined the expression profiles of the three SARS-CoV-2…
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Keywords:
epithelial cells;
airway epithelial;
expression;
human airway ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179659
Abstract: COVID-19, caused by the highly transmissible severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has rapidly spread and become a pandemic since its outbreak in 2019. We have previously discovered that aloperine is a new privileged scaffold…
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Keywords:
quinolizidines novel;
entry;
entry inhibitors;
cov entry ... See more keywords