Host-directed editing of the SARS-CoV-2 genome
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2020.10.092
Abstract: The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on… read more here.
Keywords: genome host; host directed; directed editing; cov genome ... See more keywords
Inverted repeats in coronavirus SARS-CoV-2 genome manifest the evolution events
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Theoretical Biology"
DOI: 10.1016/j.jtbi.2021.110885
Abstract: The world faces a great unforeseen challenge through the COVID-19 pandemic caused by coronavirus SARS-CoV-2. The virus genome structure and evolution are positioned front and center for further understanding insights on vaccine development, monitoring of… read more here.
Keywords: coronavirus sars; inverted repeats; evolution events; cov genome ... See more keywords
Footprints of SARS-CoV-2 genome diversity in Pakistan, 2020–2021
Sign Up to like & getrecommendations! Published in 2022 at "Virologica Sinica"
DOI: 10.1016/j.virs.2022.01.009
Abstract: Highlights • Highlights the circulating strains in Pakistan.• B.1 and B.1.36.31 are the dominant lineages during first and second wave of pandemic, respectively.• B.1.1.7, B.1.351 and B.1.617.2 are the dominant lineages during third and fourth… read more here.
Keywords: pakistan 2020; sars cov; genome diversity; footprints sars ... See more keywords
Synthetic Platforms for Characterizing and Targeting of SARS-CoV-2 Genome Capping Enzymes
Sign Up to like & getrecommendations! Published in 2022 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.2c00359
Abstract: Essential viral enzymes have been successfully targeted to combat the diseases caused by emerging pathogenic RNA viruses (e.g., viral RNA-dependent RNA polymerase). Because of the conserved nature of such viral enzymes, therapeutics targeting these enzymes… read more here.
Keywords: mtase; cov genome; rna; targeting sars ... See more keywords
The UCSC SARS-CoV-2 Genome Browser
Sign Up to like & getrecommendations! Published in 2020 at "Nature genetics"
DOI: 10.1038/s41588-020-0700-8
Abstract: The UCSC SARS-CoV-2 Genome Browser ( https://genome.ucsc.edu/covid19.html ) is an adaptation of our popular genome-browser visualization tool for this virus, containing many annotation tracks and new features, including conservation with similar viruses, immune epitopes, RT–PCR… read more here.
Keywords: ucsc sars; genome browser; cov genome; browser ... See more keywords
Single-nucleotide conservation state annotation of the SARS-CoV-2 genome
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02231-w
Abstract: Given the global impact and severity of COVID-19, there is a pressing need for a better understanding of the SARS-CoV-2 genome and mutations. Multi-strain sequence alignments of coronaviruses (CoV) provide important information for interpreting the… read more here.
Keywords: conservation states; single nucleotide; multi strain; cov genome ... See more keywords
Deep Learning for SARS COV-2 Genome Sequences
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Access"
DOI: 10.1109/access.2021.3073728
Abstract: The SARS-CoV-2 virus which originated in Wuhan, China has since spread throughout the world and is affecting millions of people. When there is a novel virus outbreak, it is crucial to quickly determine if the… read more here.
Keywords: cov genome; neural network; learning sars; regulatory motifs ... See more keywords
Putative Host-Derived Insertions in the Genomes of Circulating SARS-CoV-2 Variants
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.00179-22
Abstract: Throughout the COVID-19 pandemic, the sequencing of SARS-CoV-2 genomes has revealed the presence of insertions in multiple globally circulating lineages of SARS-CoV-2, including the Omicron variant. The human genome has been suggested to be the… read more here.
Keywords: derived insertions; cov genome; circulating sars; host derived ... See more keywords
Stability of SARS-CoV-2 phylogenies
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DOI: 10.1371/journal.pgen.1009175
Abstract: The SARS-CoV-2 pandemic has led to unprecedented, nearly real-time genetic tracing due to the rapid community sequencing response. Researchers immediately leveraged these data to infer the evolutionary relationships among viral samples and to study key… read more here.
Keywords: sars cov; stability sars; cov phylogenies; cov genome ... See more keywords
Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0260438
Abstract: The Coronavirus Disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). As of May 25th, 2021 there were 2.059.941 SARS-COV2 genome sequences that have been submitted to the… read more here.
Keywords: protein structure; sars cov; spike protein; structure ... See more keywords
Detection of SARS-CoV-2 genome in the air, surfaces, and wastewater of the referral hospitals, Gorgan, north of Iran
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Microbiology"
DOI: 10.18502/ijm.v14i5.10954
Abstract: Background and Objectives: Coronavirus disease 2019 (COVID-19) is a pandemic caused by the novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Knowing the virus’s behavior and its persistence in different environments are crucial and… read more here.
Keywords: samples taken; cov genome; air; referral hospitals ... See more keywords