Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors
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DOI: 10.2478/acph-2020-0024
Abstract: Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries. Herein we investigated the anti-MERS-CoV activity of newly… read more here.
Keywords: design synthesis; cov helicase; helicase; mers cov ... See more keywords
Therapeutic potential of compounds targeting SARS-CoV-2 helicase
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1062352
Abstract: The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored as a drug target, the… read more here.
Keywords: therapeutic potential; compounds targeting; cov helicase; helicase ... See more keywords
Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 Helicase
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DOI: 10.3390/ijms23147704
Abstract: Repurposing of existing drugs is a rapid way to find potential new treatments for SARS-CoV-2. Here, we applied a virtual screening approach using Autodock Vina and molecular dynamic simulation in tandem to screen and calculate… read more here.
Keywords: covid therapies; top hits; cov helicase; potential covid ... See more keywords