Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Biophysics and Molecular Biology"
DOI: 10.1016/j.pbiomolbio.2021.02.002
Abstract: Arrival of the novel SARS-CoV-2 has launched a worldwide effort to identify both pre-approved and novel therapeutics targeting the viral proteome, highlighting the urgent need for efficient drug discovery strategies. Even with effective vaccines, infection… read more here.
Keywords: adp ribose; sars cov; structure; parg ... See more keywords
High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain
Sign Up to like & getrecommendations! Published in 2021 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.1c00721
Abstract: Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are critical for replication and virus-induced pathogenesis; therefore, these enzymes are a promising target for antiviral… read more here.
Keywords: cov mac1; high throughput; macrodomain; sars cov ... See more keywords