Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice
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DOI: 10.1016/j.ebiom.2021.103381
Abstract: Background An ideal animal model to study SARS-coronavirus 2 (SARS-CoV-2) pathogenesis and evaluate therapies and vaccines should reproduce SARS-CoV-2 infection and recapitulate lung disease like those seen in humans. The angiotensin-converting enzyme 2 (ACE2) is… read more here.
Keywords: mouse adapted; wbp; q493k q498h; sars cov ... See more keywords