Validation of a quantitative lateral flow immunoassay (LFIA)-based point-of-care (POC) rapid test for SARS-CoV-2 neutralizing antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Virology"
DOI: 10.1007/s00705-022-05422-w
Abstract: With the widespread use of coronavirus disease 2019 (COVID-19) vaccines, a rapid and reliable method to detect SARS-CoV-2 neutralizing antibodies (NAbs) is extremely important for monitoring vaccine effectiveness and immunity in the population. The purpose… read more here.
Keywords: test; cov neutralizing; sars cov; neutralizing antibodies ... See more keywords
Epitope Analysis of Anti-SARS-CoV-2 Neutralizing Antibodies
Sign Up to like & getrecommendations! Published in 2021 at "Current Medical Science"
DOI: 10.1007/s11596-021-2453-8
Abstract: Coronavirus disease 2019 is threatening thousands of millions of people around the world. In the absence of specific and highly effective medicines, the treatment of infected persons is still very challenging. As therapeutics, neutralizing antibodies… read more here.
Keywords: analysis anti; neutralizing antibodies; cov neutralizing; anti sars ... See more keywords
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
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DOI: 10.1038/s41467-021-26539-7
Abstract: Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor binding domain (RBD) specific monoclonal antibodies (mAbs), 58G6, 510A5… read more here.
Keywords: efficacy; cov neutralizing; neutralizing antibodies; potent sars ... See more keywords
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-29288-3
Abstract: COVID-19 pathogen SARS-CoV-2 has infected hundreds of millions and caused over 5 million deaths to date. Although multiple vaccines are available, breakthrough infections occur especially by emerging variants. Effective therapeutic options such as monoclonal antibodies… read more here.
Keywords: sars cov; potency; antibody; emerging variants ... See more keywords
SARS‐CoV‐2 neutralizing antibodies for COVID‐19: Outcomes for bamlanivimab versus bamlanivimab‐etesevimab combination in a racially diverse cohort of patients with significant comorbidities
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13694
Abstract: Anti‐spike monoclonal antibodies (MAB) including bamlanivimab (BAM) and bamlanivimab/etesevimab (BAM/E) have shown reduced hospitalization rates for non‐severe coronavirus disease 2019 (COVID‐19) in clinical trials. Recent data have provided real‐world hospitalization rates for high‐risk patients treated… read more here.
Keywords: cov neutralizing; neutralizing antibodies; bamlanivimab; cohort ... See more keywords
SARS-CoV-2 Neutralizing Antibodies for COVID-19 Prevention and Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Annual review of medicine"
DOI: 10.1146/annurev-med-042420-113838
Abstract: Prophylactic and therapeutic drugs are urgently needed to combat coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over the past year, SARS-CoV-2 neutralizing antibodies have been developed for preventive or… read more here.
Keywords: medicine; covid prevention; neutralizing antibodies; cov neutralizing ... See more keywords
Evaluation of SARS-CoV-2 neutralizing antibodies using a vesicular stomatitis virus possessing SARS-CoV-2 spike protein
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DOI: 10.1186/s12985-021-01490-7
Abstract: Background SARS-CoV-2 is a novel coronavirus that emerged in 2019 and is now classified in the genus Coronavirus with closely related SARS-CoV. SARS-CoV-2 is highly pathogenic in humans and is classified as a biosafety level… read more here.
Keywords: neutralizing antibodies; evaluation sars; cov neutralizing; antibodies using ... See more keywords
The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
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DOI: 10.1371/journal.pone.0253487
Abstract: Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19, little is known about their mechanism(s) of action or effective dosing windows. We report the generation and development of SC31, a potent SARS-CoV-2 neutralizing antibody, isolated from… read more here.
Keywords: sc31; antibody; therapeutic efficacy; cov neutralizing ... See more keywords
A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity
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DOI: 10.3389/fimmu.2022.1041860
Abstract: Accurate detection of SARS-CoV-2 neutralizing antibody (nAb) is critical for assessing the immunity levels after virus infection or vaccination. As fast, cost-effective alternatives to viral infection-based assays, competitive binding (CB) assays were developed to quantitate… read more here.
Keywords: cov neutralizing; iace2 rbd; soluble tagged; ace2 ... See more keywords
Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies
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DOI: 10.3389/fmicb.2023.1122868
Abstract: COVID-19 pandemic is a global public health emergency. Despite extensive research, there are still few effective treatment options available today. Neutralizing-antibody-based treatments offer a broad range of applications, including the prevention and treatment of acute… read more here.
Keywords: cov neutralizing; neutralizing antibodies; antibody based; neutralizing antibody ... See more keywords
Generation of a Nebulizable CDR-Modified MERS-CoV Neutralizing Human Antibody
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DOI: 10.3390/ijms20205073
Abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) induces severe aggravating respiratory failure in infected patients, frequently resulting in mechanical ventilation. As limited therapeutic antibody is accumulated in lung tissue following systemic administration, inhalation is newly recognized… read more here.
Keywords: human antibody; residues replaced; neutralizing human; antibody ... See more keywords