Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25166-6
Abstract: There is currently a lack of effective drugs to treat people infected with SARS-CoV-2, the cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural protein 13 (NSP13) has been identified as a target for anti-virals… read more here.
Keywords: mechanism; cov nsp13; helicase; sars cov ... See more keywords
Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.2022659
Abstract: Abstract On account of its crucial role in the virus life cycle, SARS-COV-2 NSP13 helicase enzyme was exploited as a promising target to identify a novel potential inhibitor using multi-stage structure-based drug discovery approaches. Firstly,… read more here.
Keywords: cov nsp13; stage structure; nsp13 helicase; multi stage ... See more keywords
Toward wide-spectrum antivirals against coronaviruses: Molecular characterization of SARS-CoV-2 NSP13 helicase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj4526
Abstract: Molecular dynamics simulations are used to unravel the SARS-CoV-2 NSP13 behavior in interaction with natural ligands and inhibitors. read more here.
Keywords: spectrum antivirals; cov nsp13; wide spectrum; antivirals coronaviruses ... See more keywords