The utility of SARS‐CoV‐2 nucleocapsid protein in laboratory diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24534
Abstract: The Coronavirus Disease 2019 (COVID‐19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which has now become a global pandemic owing to its high transmissibility. The SARS‐CoV‐2 nucleocapsid protein tests are playing… read more here.
Keywords: nucleocapsid protein; cov nucleocapsid; sars cov; utility sars ... See more keywords
TRIM21 promotes ubiquitination of SARS‐CoV‐2 nucleocapsid protein to regulate innate immunity
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28719
Abstract: The innate immune response is the first line of host defense against viral infections, but its role in immunity against SARS‐CoV‐2 remains unclear. By using immunoprecipitation coupled with mass spectroscopy, we observed that the E3… read more here.
Keywords: nucleocapsid protein; trim21; cov nucleocapsid; innate ... See more keywords
SARS‐CoV‐2 nucleocapsid: Biological functions and implication for disease diagnosis and vaccine design
Sign Up to like & getrecommendations! Published in 2023 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.2431
Abstract: The coronavirus disease 2019 (COVID‐19) pandemic is transmitted by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has affected millions of people all around the world, leading to more than 6.5 million deaths. The nucleocapsid… read more here.
Keywords: biological functions; cell; disease; cov nucleocapsid ... See more keywords
Electrochemical Immunoassay for the Detection of SARS-CoV-2 Nucleocapsid Protein in Nasopharyngeal Samples.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04966
Abstract: Point-of-care (POC) methods currently available for detecting SARS-CoV-2 infections still lack accuracy. Here, we report the development of a highly sensitive electrochemical immunoassay capable of quantitatively detecting the presence of the SARS-CoV-2 virus in patient… read more here.
Keywords: electrochemical immunoassay; sars cov; detection; nasopharyngeal samples ... See more keywords
Hydrophobic Localized Enrichment of Co-reactants to Enhance Electrochemiluminescence of Conjugated Polymers for Detecting SARS-CoV-2 Nucleocapsid Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.1c05407
Abstract: The enrichment of co-reactants is one of the keys to improving the sensitivity of electrochemiluminescence (ECL) detection. This work developed a novel hydrophobic localized enrichment strategy of co-reactants utilizing the inner hydrophobic cavity of β-cyclodextrin… read more here.
Keywords: hydrophobic localized; enrichment reactants; cov nucleocapsid; detection ... See more keywords
Electrochemical Capillary-Flow Immunoassay for Detecting Anti-SARS-CoV-2 Nucleocapsid Protein Antibodies at the Point of Care.
Sign Up to like & getrecommendations! Published in 2021 at "ACS sensors"
DOI: 10.1021/acssensors.1c01527
Abstract: Rapid and inexpensive serological tests for SARS-CoV-2 antibodies are needed to conduct population-level seroprevalence surveillance studies and can improve diagnostic reliability when used in combination with viral tests. Here, we report a novel low-cost electrochemical… read more here.
Keywords: cov nucleocapsid; electrochemical capillary; point care; capillary flow ... See more keywords
Smartphone-Based High-Throughput Fiber-Integrated Immunosensing System for Point-of-Care Testing of the SARS-CoV-2 Nucleocapsid Protein
Sign Up to like & getrecommendations! Published in 2022 at "ACS Sensors"
DOI: 10.1021/acssensors.2c00754
Abstract: To control the coronavirus disease 2019 (COVID-19) pandemic, there is an urgent need for simple, rapid, and reliable detection methods to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, especially in community hospitals or… read more here.
Keywords: nucleocapsid protein; smartphone based; high throughput; cov nucleocapsid ... See more keywords
Structural domains of SARS-CoV-2 nucleocapsid protein coordinate to compact long nucleic acid substrates
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1179
Abstract: Abstract The SARS-CoV-2 nucleocapsid (N) protein performs several functions including binding, compacting, and packaging the ∼30 kb viral genome into the viral particle. N protein consists of two ordered domains, with the N terminal domain… read more here.
Keywords: nucleocapsid protein; cov nucleocapsid; nucleic acid; sars cov ... See more keywords
Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00324-23
Abstract: As SARS-CoV-2 continues to evolve, a structural and genetic understanding of key viral epitopes will be essential to the development of next-generation diagnostics and vaccines. This study uses structural biology and epitope mapping to define… read more here.
Keywords: biology; cov nucleocapsid; epitope mapping; sars cov ... See more keywords
Identification and functional analysis of the SARS-COV-2 nucleocapsid protein
Sign Up to like & getrecommendations! Published in 2021 at "BMC Microbiology"
DOI: 10.1186/s12866-021-02107-3
Abstract: Background A severe form of pneumonia, named coronavirus disease 2019 (COVID-19) by the World Health Organization is widespread on the whole world. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was proved to be the… read more here.
Keywords: protein; cov nucleocapsid; analysis sars; cov protein ... See more keywords
Seroprevalence and longevity of SARS-CoV-2 nucleocapsid antigen-IgG among health care workers in a large COVID-19 public hospital in Saudi Arabia: A prospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0272818
Abstract: Seroprevalence of SARS-CoV-2 IgG among health care workers (HCWs) is crucial to inform infection control programs. Conflicting reports have emerged on the longevity of SARS-CoV-2 IgG. Our objective is to describe the prevalence of SARS-CoV-2… read more here.
Keywords: saudi arabia; seroprevalence; cov nucleocapsid; sars cov ... See more keywords