Detailed epitope mapping of SARS-CoV-2 nucleoprotein reveals specific immunoresponse in cats and dogs housed with COVID-19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Research in Veterinary Science"
DOI: 10.1016/j.rvsc.2021.12.020
Abstract: Since the initial emergence in December 2019, the novel Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been reported in over 200 countries, representing an unprecedented challenge related to disease control worldwide. In this context, cases of… read more here.
Keywords: housed covid; mapping sars; sars cov; cov nucleoprotein ... See more keywords
Development of a Phage Display Panning Strategy Utilizing Crude Antigens: Isolation of MERS-CoV Nucleoprotein human antibodies
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DOI: 10.1038/s41598-019-42628-6
Abstract: Antibody phage display has been pivotal in the quest to generate human monoclonal antibodies for biomedical and research applications. Target antigen preparation is a main bottleneck associated with the panning process. This includes production complexity,… read more here.
Keywords: cov nucleoprotein; phage display; monoclonal antibodies; display ... See more keywords
The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm4034
Abstract: The processes of genome replication and transcription of SARS-CoV-2 represent important targets for viral inhibition. Betacoronaviral nucleoprotein (N) is a highly dynamic cofactor of the replication-transcription complex (RTC), whose function depends on an essential interaction… read more here.
Keywords: interaction; intrinsically disordered; cov nucleoprotein; disordered sars ... See more keywords
Neuropeptides, New Ligands of SARS-CoV-2 Nucleoprotein, a Potential Link between Replication, Inflammation and Neurotransmission
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27228094
Abstract: This work identifies new ligands of the nucleoprotein N of SARS-CoV-2 by in silico screening, which used a new model of N, built from an Alphafold model refined by molecular dynamic simulations. The ligands were… read more here.
Keywords: replication; cov nucleoprotein; neuropeptides new; new ligands ... See more keywords
Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14061141
Abstract: COVID-19 caused by SARS-CoV-2 is continuing to spread around the world and drastically affect our daily life. New strains appear, and the severity of the course of the disease itself seems to be decreasing, but… read more here.
Keywords: cov nucleoprotein; covid; autoimmune effect; antibodies sars ... See more keywords