SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98
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DOI: 10.1128/mbio.00065-21
Abstract: SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is an RNA virus with a large genome that encodes multiple accessory proteins. While these accessory proteins are not required for growth in vitro, they can… read more here.
Keywords: rae1 nup98; mrna; interactions rae1; cov orf6 ... See more keywords
Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 Secretion
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DOI: 10.3390/v14061273
Abstract: A weak production of INF-β along with an exacerbated release of pro-inflammatory cytokines have been reported during infection by the novel SARS-CoV-2 virus. SARS-CoV-2 encodes several proteins that are able to counteract the host immune… read more here.
Keywords: orf6 protein; nucleopore traffic; traffic hindered; cov orf6 ... See more keywords