SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses
Sign Up to like & getrecommendations! Published in 2022 at "International Immunology"
DOI: 10.1093/intimm/dxac044
Abstract: Many patients with severe COVID-19 suffer from pneumonia, and thus elucidation of the mechanisms underlying the development of such severe pneumonia is important. The ORF8 protein is a secreted protein of SARS-CoV-2, whose in vivo… read more here.
Keywords: cov orf8; orf8 protein; viral cytokine; sars cov ... See more keywords
SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00011-23
Abstract: Although SARS-CoV-2 is basically regarded as a homolog of SARS-CoV, with their genomic structure and the majority of their genes being highly homologous, the ORF8 genes of SARS-CoV and SARS-CoV-2 are distinct. The SARS-CoV-2 ORF8… read more here.
Keywords: endoplasmic reticulum; stress; cov orf8; orf8 protein ... See more keywords
Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8
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DOI: 10.1128/mbio.00402-22
Abstract: Patients infected with SARS-CoV-2 variants lacking open reading frame 8 (ORF8) have been associated with milder infection and disease outcome, but the molecular mechanism behind how this viral accessory protein mediates disease pathogenesis is not… read more here.
Keywords: cov orf8; viral mimicry; orf8 viral; interleukin 17a ... See more keywords
SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1035559
Abstract: SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The genome of SARS-CoV-2 encodes nine accessory proteins that are involved in host-pathogen interaction. ORF8 is unique among these accessory proteins. SARS-CoV-2 ORF8 shares a surprisingly… read more here.
Keywords: structure; cov orf8; one protein; sars cov ... See more keywords
SARS-CoV-2 ORF8: A Rapidly Evolving Immune and Viral Modulator in COVID-19
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DOI: 10.3390/v15040871
Abstract: The COVID-19 pandemic has resulted in upwards of 6.8 million deaths over the past three years, and the frequent emergence of variants continues to strain global health. Although vaccines have greatly helped mitigate disease severity,… read more here.
Keywords: rapidly evolving; cov orf8; covid; evolving immune ... See more keywords
SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2300110
Abstract: SARS-CoV-2 has caused an estimated 7 million deaths worldwide to date. A secreted SARS-CoV-2 accessory protein, known as open reading frame 8 (ORF8), elicits inflammatory pulmonary cytokine responses and is associated with disease severity in… read more here.
Keywords: orf8 mediates; cov orf8; macrophages monocytes; sars cov ... See more keywords