Design and Evaluation of a Novel Peptide–Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease
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DOI: 10.1021/acs.jmedchem.1c02022
Abstract: Coronavirus disease 2019 (COVID-19) pandemic, a global health threat, was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 papain-like cysteine protease (PLpro) was recognized as a promising drug target because of multiple… read more here.
Keywords: sars cov; drug; cov papain; novel peptide ... See more keywords
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease
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DOI: 10.1021/acs.jmedchem.2c00303
Abstract: SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines and small-molecule antivirals is vital in combating the pandemic. The viral polymerase inhibitors remdesivir and molnupiravir and the viral main protease inhibitor… read more here.
Keywords: protease; like protease; plpro inhibitors; cov papain ... See more keywords
Investigating Derivatives of Tanshinone IIA Sulfonate Sodium and Chloroxine for Their Inhibition Activities against the SARS-CoV-2 Papain-like Protease
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DOI: 10.1021/acsomega.2c06675
Abstract: SARS-CoV-2 has caused a global pandemic of COVID-19, posing a huge threat to public health. The SARS-CoV-2 papain-like cysteine protease (PLpro) plays a significant role in virus replication and host immune regulation, which is a… read more here.
Keywords: derivatives tanshinone; tanshinone iia; chloroxine; cov papain ... See more keywords
Abstract 10067: A Nitric Oxide Donor Binds to SARS-CoV-2 Papain-Like Protease with Therapeutic Implications
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DOI: 10.1161/circ.144.suppl_1.10067
Abstract: Novel compounds developed as nitric oxide (NO) donors for cardiovascular diseases were created by linking an urea-like NO donor to the 5-carbon of the generic agent isosorbide-2-nitrate. NO also appears to have antiviral effects on… read more here.
Keywords: sars cov; nitric oxide; cov papain; papain like ... See more keywords
Discovery of the Cryptic Sites of SARS-CoV-2 Papain-like Protease and Analysis of Its Druggability
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DOI: 10.3390/ijms231911265
Abstract: In late 2019, a new coronavirus (CoV) caused the outbreak of a deadly respiratory disease, resulting in the COVID-19 pandemic. In view of the ongoing pandemic, there is an immediate need to find drugs to… read more here.
Keywords: protease; druggability; discovery cryptic; cov papain ... See more keywords
Search for Novel Potent Inhibitors of the SARS-CoV-2 Papain-like Enzyme: A Computational Biochemistry Approach
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DOI: 10.3390/ph15080986
Abstract: The rapid emergence and spread of new variants of coronavirus type 2, as well as the emergence of zoonotic viruses, highlights the need for methodologies that contribute to the search for new pharmacological treatments. In… read more here.
Keywords: search novel; cov papain; papain like; biochemistry ... See more keywords