Structure-Based Screening to Discover New Inhibitors for Papain-like Proteinase of SARS-CoV-2: An In Silico Study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.0c00836
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses a multifunctional papain-like proteinase (PLpro), which mediates the processing of the viral replicase polyprotein. Inhibition of PLpro has been shown to suppress the viral replication. This study… read more here.
Keywords: like proteinase; cov plpro; study; proteinase ... See more keywords
Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011065
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses—including SARS-CoV, MERS-CoV,… read more here.
Keywords: cov plpro; viral replication; ubiquitin variants; site ... See more keywords
Hydroxytyrosol Recovers SARS-CoV-2-PLpro-Dependent Impairment of Interferon Related Genes in Polarized Human Airway, Intestinal and Liver Epithelial Cells
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DOI: 10.3390/antiox11081466
Abstract: The SARS-CoV-2 pandemic has caused approximately 6.3 million deaths, mainly due to the acute respiratory distress syndrome or multi-organ failure that characterizes COVID-19 acute disease. Post-acute COVID-19 syndrome, also known as long-COVID, is a condition… read more here.
Keywords: cov plpro; long covid; polarized human; epithelial cells ... See more keywords
Liposome-Mediated Delivery of MERS Antigen Induces Potent Humoral and Cell-Mediated Immune Response in Mice
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DOI: 10.3390/molecules27020403
Abstract: The advancements in the field of nanotechnology have provided a great platform for the development of effective antiviral vaccines. Liposome-mediated delivery of antigens has been shown to induce the antigen-specific stimulation of the humoral and… read more here.
Keywords: cov plpro; mice; drvs mers; mers cov ... See more keywords