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Published in 2021 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.0c00815
Abstract: Two proteases produced by the SARS-CoV-2 virus, the main protease and papain-like protease, are essential for viral replication and have become the focus of drug development programs for treatment of COVID-19. We screened a highly…
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Keywords:
protease;
targeting sars;
covid;
challenges targeting ... See more keywords
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Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84782-w
Abstract: The lack of coronavirus-specific antiviral drugs has instigated multiple drug repurposing studies to redirect previously approved medicines for the treatment of SARS-CoV-2, the coronavirus behind the ongoing COVID-19 pandemic. A recent, large-scale, retrospective clinical study…
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Keywords:
famotidine;
proteases virus;
effect famotidine;
cov proteases ... See more keywords
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Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra05976a
Abstract: Vernonia amygdalina derived phytochemicals as potential dual-target directed inhibitors of SARS-CoV-2 proteases from computational study perspective.
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Keywords:
dual target;
target directed;
inhibitors sars;
cov proteases ... See more keywords
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Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2021.819165
Abstract: The emergence of severe acute respiratory syndrome (SARS-CoV-2) in 2019 marked the third occurrence of a highly pathogenic coronavirus in the human population since 2003. As the death toll surpasses 5 million globally and economic…
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Keywords:
antiviral development;
proteases covid;
targeting sars;
sars cov ... See more keywords
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Published in 2021 at "Data"
DOI: 10.3390/data6090099
Abstract: The SARS-CoV-2 coronavirus expresses two essential proteases: firstly, the 3Chymotrypsin-like protease (3CLpro) or main protease (Mpro), and secondly, the papain-like protease (PLpro), both of which are considered as viable drug targets for the inhibition of…
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Keywords:
coli;
cov2;
cov proteases;
bl21 ... See more keywords