Knowledge‐based structural models of SARS‐CoV‐2 proteins and their complexes with potential drugs
Sign Up to like & getrecommendations! Published in 2020 at "Febs Letters"
DOI: 10.1002/1873-3468.13806
Abstract: The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID‐19) caused by the novel coronavirus SARS‐CoV‐2 a pandemic. There is, however, no confirmed anti‐COVID‐19 therapeutic currently. In order to assist structure‐based discovery efforts… read more here.
Keywords: cov proteins; structural models; models sars; knowledge based ... See more keywords
Differential mutation profile of SARS-CoV-2 proteins across deceased and asymptomatic patients
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-Biological Interactions"
DOI: 10.1016/j.cbi.2021.109598
Abstract: Background The SARS-CoV-2 infection has spread at an alarming rate with many places showing multiple peaks in incidence. Present study analyzes a total of 332 SARS-CoV-2 genome sequences from 114 asymptomatic and 218 deceased patients… read more here.
Keywords: deleterious variants; mutation profile; cov proteins; sars cov ... See more keywords
Development and Validation of a Multiplex, Bead-Based Assay to Detect Antibodies Directed Against SARS-CoV-2 Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation"
DOI: 10.1097/tp.0000000000003524
Abstract: BACKGROUND Transplant recipients who develop COVID-19 may be at increased risk for morbidity and mortality. Determining the status of antibodies against SARS-CoV-2 in both candidates and recipients will be important to understand the epidemiology and… read more here.
Keywords: development validation; cov proteins; detect antibodies; sars cov ... See more keywords
Adenovirus 5 Vectors Expressing SARS-CoV-2 Proteins
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DOI: 10.1128/msphere.00998-21
Abstract: The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus has brought untold personal and economic suffering to the world. Intense research has made tremendous progress in understanding how this virus works, yet much research remains to… read more here.
Keywords: cov proteins; cov coronavirus; virus; research ... See more keywords
Computational Study on the Inhibitory Effect of Natural Compounds against the SARS-CoV-2 Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Bioinorganic Chemistry and Applications"
DOI: 10.1155/2022/8635054
Abstract: COVID-19 is more virulent and challenging to human life. In India, the Ministry of AYUSH recommended some strategies through Siddha, homeopathy, and other methods to effectively manage COVID-19 (Guidelines for AYUSH Clinical Studies in COVID-19,… read more here.
Keywords: natural compounds; kabasura kudineer; cov proteins; study ... See more keywords
Prediction of the Effects of Nonsynonymous Variants on SARS-CoV-2 Proteins.
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DOI: 10.12688/f1000research.72904.1
Abstract: Background: SARS-CoV-2 virus is a highly transmissible pathogen that causes COVID-19. The outbreak originated in Wuhan, China in December 2019. A number of nonsynonymous mutations located at different SARS-CoV-2 proteins have been reported by multiple studies. However, there are limited computational studies on the biological impacts of these mutations on the structure and… read more here.
Keywords: nonsynonymous mutations; prediction; cov proteins; orf1a nsp5 ... See more keywords
Prediction of the effects of the top 10 nonsynonymous variants from 30229 SARS-CoV-2 strains on their proteins
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DOI: 10.12688/f1000research.72904.2
Abstract: Background: SARS-CoV-2 virus is a highly transmissible pathogen that causes COVID-19. The outbreak originated in Wuhan, China in December 2019. A number of nonsynonymous mutations located at different SARS-CoV-2 proteins have been reported by multiple… read more here.
Keywords: top nonsynonymous; effects top; nonsynonymous mutations; cov proteins ... See more keywords
Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens
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DOI: 10.1371/journal.pone.0259165
Abstract: The rapid, sensitive and specific detection of SARS-CoV-2 is critical in responding to the current COVID-19 outbreak. In this proof-of-concept study, we explored the potential of targeted mass spectrometry (MS) based proteomics for the detection… read more here.
Keywords: detection; proteomics tool; clinical specimens; targeted proteomics ... See more keywords
Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010118
Abstract: Antiphospholipid antibodies (aPL), assumed to cause antiphospholipid syndrome (APS), are notorious for their heterogeneity in targeting phospholipids and phospholipid-binding proteins. The persistent presence of Lupus anticoagulant and/or aPL against cardiolipin and/or β2-glycoprotein I have been… read more here.
Keywords: infection; antibody response; sars cov; cov proteins ... See more keywords
Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins
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DOI: 10.3389/fimmu.2021.714511
Abstract: Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of… read more here.
Keywords: lectin pathway; activation; cov proteins; sars cov ... See more keywords
Roles and functions of SARS-CoV-2 proteins in host immune evasion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.940756
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes 16 non-structural proteins (NSPs), four structural proteins, and nine accessory proteins that… read more here.
Keywords: cov proteins; immune evasion; host immune; sars cov ... See more keywords