Targeting SARS‐CoV‐2 RBD interface: a supervised computational data‐driven approach to identify potential modulators
Sign Up to like & getrecommendations! Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000259
Abstract: Coronavirus disease 2019 (COVID‐19) has spread out as a pandemic threat affecting over 2 million people. The infectious process initiates via binding of SARS‐CoV‐2 Spike (S) glycoprotein to host angiotensin‐converting enzyme 2 (ACE2). The interaction… read more here.
Keywords: cov rbd; targeting sars; supervised computational; rbd interface ... See more keywords
HBD-2 binds SARS-CoV-2 RBD and blocks viral entry: Strategy to combat COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.103856
Abstract: New approaches to complement vaccination are needed to combat the spread of SARS-CoV-2 and stop COVID-19 related deaths and medical complications. Human beta defensin 2 (hBD-2) is a naturally occurring epithelial cell derived host defense… read more here.
Keywords: sars cov; combat; cov rbd; covid ... See more keywords
Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-020-0400-4
Abstract: The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute… read more here.
Keywords: development; cov rbd; coronavirus; rbd ... See more keywords
Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc02267a
Abstract: The infection of coronavirus initiates with the binding between its spike protein receptor binding domain (RBD) and a human cellular receptor called angiotensin-converting enzyme 2 (ACE2). Here, we construct truncated ACE2 peptide-conjugated gold nanoparticles as… read more here.
Keywords: cov rbd; ace2 peptide; binding sars; rbd ... See more keywords
ACE2 glycans preferentially interact with SARS-CoV-2 over SARS-CoV.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc02305e
Abstract: We report a distinct difference in the interactions of the glycans of the host-cell receptor, ACE2, with SARS-CoV-2 and SARS-CoV S-protein receptor-binding domains (RBDs). Our analysis demonstrates that the ACE2 glycan at N322 enhances interactions… read more here.
Keywords: cov sars; cov rbd; glycans preferentially; sars cov ... See more keywords
Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2047144
Abstract: ABSTRACT There remains an unmet need for globally deployable, low-cost therapeutics for the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Previously, we reported on the isolation and in vitro characterization of a potent… read more here.
Keywords: rbd; cov rbd; syrian hamster; covnb 112 ... See more keywords
Are SARS-CoV-2 Antibodies Detectable in Human Milk After Vaccination Against COVID-19?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piac024
Abstract: Abstract Background Human milk (HM) permits transfer of immunity against infections to infants via bioactive factors. The role of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in HM is poorly understood [1, 2]. This… read more here.
Keywords: breastfeeding months; cov antibodies; cov rbd; anti sars ... See more keywords
Possible Cross-Reactivity of Feline and White-Tailed Deer Antibodies against the SARS-CoV-2 Receptor Binding Domain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00250-22
Abstract: We report cross-reactive antibodies from prepandemic cats and postpandemic South Carolina white-tailed deer that are specific for that SARS-CoV RBD. There are several potential explanations for this cross-reactivity, each with important implications to coronavirus disease… read more here.
Keywords: white tailed; tailed deer; cross reactivity; cov rbd ... See more keywords
Application and Validation of SARS-CoV-2 RBD Neutralizing ELISA Assay.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Razi Institute"
DOI: 10.22092/ari.2021.356677.1890
Abstract: The establishment of an approach for detecting the anti-severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-receptor-binding domain (RBD) neutralizing antibodies (nAbs) by a safe, easy, and rapid technique without requiring the use of live viruses is essential… read more here.
Keywords: rbd; rbd neutralizing; neutralizing elisa; cov rbd ... See more keywords
A Computational Approach to Evaluate the Combined Effect of SARS-CoV-2 RBD Mutations and ACE2 Receptor Genetic Variants on Infectivity: The COVID-19 Host-Pathogen Nexus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.707194
Abstract: SARS-CoV-2 infectivity is largely determined by the virus Spike protein binding to the ACE2 receptor. Meanwhile, marked infection rate differences were reported between populations and individuals. To understand the disease dynamic, we developed a computational… read more here.
Keywords: cov rbd; infectivity; approach; receptor ... See more keywords
SARS-CoV-2 RBD protein enhances the oncolytic activity of the vesicular stomatitis virus
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1082191
Abstract: Despite recent advances in the research on oncolytic viruses (OVs), a better understanding of how to enhance their replication is key to improving their therapeutic index. Understanding viral replication is important to improve treatment outcomes… read more here.
Keywords: vsv; oncolytic activity; cov rbd; virus ... See more keywords