Effects of Epitranscriptomic RNA Modifications on the Catalytic Activity of the SARS‐CoV‐2 Replication Complex **
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300095
Abstract: SARS‐CoV‐2 causes individualized symptoms. Many reasons have been given. We propose that an individual's epitranscriptomic system could be responsible as well. The viral RNA genome can be subject to epitranscriptomic modifications, which can be different… read more here.
Keywords: activity sars; replication; m1a; cov replication ... See more keywords
Celastrol: A lead compound that inhibits SARS‐CoV‐2 replication, the activity of viral and human cysteine proteases, and virus‐induced IL‐6 secretion
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DOI: 10.1002/ddr.21982
Abstract: The global emergence of coronavirus disease 2019 (COVID‐19) has caused substantial human casualties. Clinical manifestations of this disease vary from asymptomatic to lethal, and the symptomatic form can be associated with cytokine storm and hyperinflammation.… read more here.
Keywords: human cysteine; cov replication; celastrol; viral human ... See more keywords
Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model
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DOI: 10.1016/j.antiviral.2018.05.007
Abstract: ABSTRACT Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) has emerged as a coronavirus infection of humans in the past 5 years. Though confined to certain geographical regions of the world, infection has been associated with a… read more here.
Keywords: cov replication; treatment; interferon; effect ... See more keywords
Potent Inhibitory Activities of the Adenosine Analogue Cordycepin on SARS-CoV-2 Replication
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DOI: 10.1021/acsomega.1c05998
Abstract: Nucleoside analogues are among the most successful bioactive classes of druglike compounds in pharmaceutical chemistry as they are well-known for their numerous effective bioactivities in humans, especially as antiviral and anticancer agents. Coronavirus disease 2019… read more here.
Keywords: adenosine analogue; cov replication; sars cov; cordycepin ... See more keywords
Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients
Sign Up to like & getrecommendations! Published in 2020 at "Cell Discovery"
DOI: 10.1038/s41421-020-00197-3
Abstract: Dear Editor, The Coronavirus disease 2019 (COVID-19) pandemic is one of the most serious global public health crises to date. As of July 12, 2020, more than 12.6 million cases of COVID-19 infection with 0.56… read more here.
Keywords: mir2911; cov replication; infection; infected patients ... See more keywords
Multi-level inhibition of coronavirus replication by chemical ER stress
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DOI: 10.1038/s41467-021-25551-1
Abstract: Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV replication. The ER stress inducer… read more here.
Keywords: cov replication; level inhibition; multi level; coronavirus ... See more keywords
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
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DOI: 10.1038/s41467-021-25796-w
Abstract: SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, responsible for over 170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and vaccinate against this pathogen all benefit from an improved… read more here.
Keywords: proteolysis; cov replication; cleavage; infection ... See more keywords
Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation
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DOI: 10.1038/s41467-021-27511-1
Abstract: Double membrane vesicles (DMVs) serve as replication organelles of plus-strand RNA viruses such as hepatitis C virus (HCV) and SARS-CoV-2. Viral DMVs are morphologically analogous to DMVs formed during autophagy, but lipids driving their biogenesis… read more here.
Keywords: sars cov; hcv sars; hepatitis virus; cov replication ... See more keywords
Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro
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DOI: 10.1038/s41598-021-97658-w
Abstract: Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19.… read more here.
Keywords: cov replication; probenecid inhibits; replication vivo; sars cov ... See more keywords
The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters
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DOI: 10.1128/mbio.03705-21
Abstract: The lack of effective antiviral treatments against SARS-CoV-2 is a significant limitation in the fight against the COVID-19 pandemic. Single-drug regimens have so far yielded limited results, indicating that combinations of antivirals might be required,… read more here.
Keywords: fda approved; sars cov; drug; cobicistat ... See more keywords
Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step
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DOI: 10.1128/spectrum.03273-22
Abstract: Honokiol is a compound that shows both anti-inflammatory and antiviral effects, and therefore its effect on SARS-CoV-2 infection was assessed. This small molecule inhibited SARS-CoV-2 replication in various cell-based infection systems, with up to an… read more here.
Keywords: effect; replication; infection; cov replication ... See more keywords