SARS‐CoV‐2 and SARS‐CoV: Virtual screening of potential inhibitors targeting RNA‐dependent RNA polymerase activity (NSP12)
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DOI: 10.1002/jmv.26222
Abstract: Since the outbreak of severe acute respiratory syndrome (SARS) in 2003, the harm caused by coronaviruses to the world cannot be underestimated. Recently, a novel coronavirus (severe acute respiratory syndrome coronavirus‐2 [SARS‐CoV‐2]) initially found to… read more here.
Keywords: virtual screening; cov sars; nsp12 nsp7; nsp8 complex ... See more keywords
SARS-CoV-2, SARS-CoV and MERS-CoV encode circular RNAs of spliceosome-independent origin.
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DOI: 10.1002/jmv.27734
Abstract: Circular RNAs (circRNAs) are a newly recognized component of the transcriptome with critical roles in autoimmune diseases and viral pathogenesis. To address the importance of circRNA in RNA viral transcriptome, we systematically identified and characterized… read more here.
Keywords: cov mers; sars cov; cov sars; spliceosome independent ... See more keywords
Bovine lactoferrin inhibits SARS‐CoV‐2 and SARS‐CoV‐1 by targeting the RdRp complex and alleviates viral infection in the hamster model
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DOI: 10.1002/jmv.28281
Abstract: Breast milk has been found to inhibit coronavirus infection, while the key components and mechanisms are unknown. We aimed to determine the components that contribute to the antiviral effects of breastmilk and explore their potential… read more here.
Keywords: blf; infection; rdrp; coronavirus ... See more keywords
Role of ORF8a as accessory protein in apoptosis induction in SARS‐CoV‐2 infection
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DOI: 10.1002/rmv.2312
Abstract: Dear editor Recently in a published article in Reviews in Medical Virology, Morais da Silva et al., described the different mechanisms that are involved in cell death process such as apoptosis, autophagy, and necrosis which… read more here.
Keywords: role orf8a; sars cov; apoptosis; cov sars ... See more keywords
Electrochemical immunosensors using electrodeposited gold nanostructures for detecting the S proteins from SARS-CoV and SARS-CoV-2
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DOI: 10.1007/s00216-022-03956-1
Abstract: This paper reports the development of a low-cost ( read more here.
Keywords: sars cov; electrochemical immunosensors; proteins sars; cov sars ... See more keywords
A Comprehensive Review of Animal Models for Coronaviruses: SARS-CoV-2, SARS-CoV, and MERS-CoV
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DOI: 10.1007/s12250-020-00252-z
Abstract: The recent outbreak of coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already affected a large population of the world. SARS-CoV-2 belongs to the same family of severe acute… read more here.
Keywords: cov mers; cov sars; animal models; coronavirus ... See more keywords
SARS-CoV, MERS-CoV and SARS-CoV-2: A Diagnostic Challenge
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DOI: 10.1016/j.measurement.2020.108335
Abstract: The highly pathogenic MERS-CoV, SARS-CoV and SARS-CoV-2 cause acute respiratory syndrome and are often fatal. These new viruses pose major problems to global health in general and primarily to infection control and public health services.… read more here.
Keywords: cov mers; cov sars; cov diagnostic; sars cov ... See more keywords
Exploring the Spike-hACE 2 Residue–Residue Interaction in Human Coronaviruses SARS-CoV-2, SARS-CoV, and HCoV-NL63
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DOI: 10.1021/acs.jcim.1c01544
Abstract: Coronaviruses (CoVs) have been responsible for three major outbreaks since the beginning of the 21st century, and the emergence of the recent COVID-19 pandemic has resulted in considerable efforts to design new therapies against coronaviruses.… read more here.
Keywords: cov hcov; interaction; hcov nl63; hace ... See more keywords
ACE2 glycans preferentially interact with SARS-CoV-2 over SARS-CoV.
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DOI: 10.1039/d1cc02305e
Abstract: We report a distinct difference in the interactions of the glycans of the host-cell receptor, ACE2, with SARS-CoV-2 and SARS-CoV S-protein receptor-binding domains (RBDs). Our analysis demonstrates that the ACE2 glycan at N322 enhances interactions… read more here.
Keywords: cov sars; cov rbd; glycans preferentially; sars cov ... See more keywords
Type I IFNs: A Blessing in Disguise or Partner in Crime in MERS-CoV-, SARS-CoV-, and SARS-CoV-2-Induced Pathology and Potential Use of Type I IFNs in Synergism with IFN-γ as a Novel Antiviral Approach Against COVID-19.
Sign Up to like & getrecommendations! Published in 2020 at "Viral immunology"
DOI: 10.1089/vim.2020.0085
Abstract: Since the end of 2019, the emergence of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has accelerated the research on host immune responses toward the coronaviruses. When there… read more here.
Keywords: sars cov; type ifns; cov sars; pathology ... See more keywords
Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2
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DOI: 10.1186/s13073-021-00943-6
Abstract: Background The emergence of SARS-CoV-2 underscores the need to better understand the evolutionary processes that drive the emergence and adaptation of zoonotic viruses in humans. In the betacoronavirus genus, which also includes SARS-CoV and MERS-CoV,… read more here.
Keywords: cov sars; emergence sars; affinity; sars cov ... See more keywords