Microscopy‐based assay for semi‐quantitative detection of SARS‐CoV‐2 specific antibodies in human sera
Sign Up to like & getrecommendations! Published in 2020 at "Bioessays"
DOI: 10.1002/bies.202000257
Abstract: Emergence of the novel pathogenic coronavirus SARS‐CoV‐2 and its rapid pandemic spread presents challenges that demand immediate attention. Here, we describe the development of a semi‐quantitative high‐content microscopy‐based assay for detection of three major classes… read more here.
Keywords: microscopy; cov specific; microscopy based; sars cov ... See more keywords
Long‐term SARS‐CoV‐2‐specific and cross‐reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology
Sign Up to like & getrecommendations! Published in 2022 at "Immunity"
DOI: 10.1002/iid3.595
Abstract: Cellular immune memory responses post coronavirus disease 2019 (COVID‐19) have been difficult to assess due to the risks of contaminating the immune response readout with memory responses stemming from previous exposure to endemic coronaviruses. The… read more here.
Keywords: sars cov; symptomatology; cellular immune; long term ... See more keywords
Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27959
Abstract: Given the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) as witnessed early in the coronavirus disease 2019 (COVID‐19) pandemic, concerns arose with the existing methods for virus disinfection and decontamination. The need… read more here.
Keywords: disinfection decontamination; disinfection; cov specific; specific data ... See more keywords
Immunodominant SARS‐CoV‐2‐specific CD4+ and CD8+ T‐cell responses elicited by inactivated vaccines in healthy adults
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28743
Abstract: Safety profiles and humoral responses to inactivated severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines have been previously assessed, but cellular immune responses to inactivated SARS‐CoV‐2 vaccines remain understudied. Here, we report the comprehensive characteristics… read more here.
Keywords: cell responses; cd4; cov specific; sars cov ... See more keywords
SARS-CoV-2-Specific and Functional Cytotoxic CD8 Cells in Primary Antibody Deficiency: Natural Infection and Response to Vaccine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-022-01256-y
Abstract: Purpose CD8 cytotoxic T cells (CTLs) play a critical role in the clearance of virally infected cells. SARS-CoV-2-specific CD8 T cells and functional CTLs in natural infections and following COVID-19 vaccine in primary antibody deficiency… read more here.
Keywords: functional ctls; cd8 cells; cd8; infection ... See more keywords
The association between micronutrients and the SARS-CoV-2-specific antibodies in convalescent patients
Sign Up to like & getrecommendations! Published in 2022 at "Infection"
DOI: 10.1007/s15010-022-01774-2
Abstract: Various micronutrients play key roles in the immune responses to viral infection, antibody synthesis, and susceptibility to infection. This study aimed to investigate the role of micronutrients on the immune responses following SARS-CoV-2 infection. To… read more here.
Keywords: igg; sars cov; infection; igm ... See more keywords
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.108728
Abstract: Virus-specific humoral and cellular immunity act synergistically to protect the host from viral infection. We interrogate the dynamic changes of virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from disease onset… read more here.
Keywords: disease; specific cells; sars cov; early induction ... See more keywords
SARS-CoV-2-specific ELISA development
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Immunological Methods"
DOI: 10.1016/j.jim.2020.112832
Abstract: Abstract Critical to managing the spread of COVID-19 is the ability to diagnose infection and define the acquired immune response across the population. While genomic tests for the novel Several Acute Respiratory Syndrome Coronavirus 2… read more here.
Keywords: elisa development; infection; exposure; sars cov ... See more keywords
B cell receptor (BCR) guided mechanotransduction: Critical hypothesis to instruct SARS-CoV-2 specific B cells to trigger proximal signalling and antibody reshaping
Sign Up to like & getrecommendations! Published in 2021 at "Medical Hypotheses"
DOI: 10.1016/j.mehy.2021.110640
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, has spread around the globe with remarkable consequences for the health of millions of people. Despite the approval of mRNA vaccines to prevent the spread… read more here.
Keywords: signalling antibody; cov specific; specific cells; proximal signalling ... See more keywords
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00301-9
Abstract: COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection. It is currently unknown as to the correlation between the magnitude of neutralizing antibody (NAb) responses and the disease severity in COVID-19 patients. In a cohort… read more here.
Keywords: neutralizing antibody; sars cov; severity; cov specific ... See more keywords
Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26137-7
Abstract: There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that the majority of PLWH with ART suppressed… read more here.
Keywords: cell responses; people living; specific cell; sars cov ... See more keywords