SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2022 at "Febs Letters"
DOI: 10.1002/1873-3468.14490
Abstract: SARS‐CoV‐2 spike (S) protein is crucial for virus invasion in COVID‐19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of… read more here.
Keywords: aggregation; cov spike; protein aggregation; spike protein ... See more keywords
Plastic Antibodies Mimicking the ACE2 Receptor for Selective Binding of SARS‐CoV‐2 Spike
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202101925
Abstract: Molecular imprinting has proven to be a versatile and simple strategy to obtain selective materials also termed “plastic antibodies” for a wide variety of species, i.e., from ions to macromolecules and viruses. However, to the… read more here.
Keywords: plastic antibodies; cov spike; molecularly imprinted; selective binding ... See more keywords
A CHO stable pool production platform for rapid clinical development of trimeric SARS-CoV-2 spike subunit vaccine antigens.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28387
Abstract: Protein expression from stably transfected Chinese hamster ovary (CHO) clones is an established but time-consuming method for manufacturing therapeutic recombinant proteins. The use of faster, alternative approaches, such as non-clonal stable pools, has been restricted… read more here.
Keywords: cov spike; trimeric sars; cho; production ... See more keywords
Pineapple Lectin AcmJRL Binds SARS‐CoV‐2 Spike Protein in a Carbohydrate‐Dependent Fashion
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200463
Abstract: The highly glycosylated spike protein of SARS‐CoV‐2 is essential for infection and constitutes a prime target for antiviral agents and vaccines. The pineapple‐derived jacalin‐related lectin AcmJRL is present in the medication bromelain in significant quantities… read more here.
Keywords: cov spike; acmjrl binds; lectin acmjrl; spike protein ... See more keywords
Potential antiviral activity of isorhamnetin against SARS‐CoV‐2 spike pseudotyped virus in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Drug Development Research"
DOI: 10.1002/ddr.21815
Abstract: Abstract Coronavirus Disease 2019 (COVID‐19) cases and deaths are still rising worldwide, there is currently no effective treatment for severe inflammation and acute lung injury caused by new coronavirus (SARS‐COV‐2) infection. Therapies to prevent or… read more here.
Keywords: spike pseudotyped; pseudotyped virus; cov spike; drug ... See more keywords
Dyslipidemia and SARS‐CoV‐2 spike antibody titres after the second and third doses of the BNT162b2 vaccine among healthcare workers in Japan
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3606
Abstract: This study aimed to examine the sex‐associated differences in the relationship between dyslipidemia and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike immunoglobulin (Ig)G antibodies among BNT162b2 vaccine recipients. read more here.
Keywords: cov spike; spike antibody; dyslipidemia sars; bnt162b2 vaccine ... See more keywords
N‐terminal domain of SARS CoV‐2 spike protein mutation associated reduction in effectivity of neutralizing antibody with vaccinated individuals
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27181
Abstract: Dear Editor The spike (S) protein is a homotrimer on the SARS‐CoV‐2 surface which targets the angiotensin‐converting enzyme‐2 in humans (ACE2). The Spike (S) coronavirus 2 (SARS‐CoV‐2) protein is a major driving force for viral… read more here.
Keywords: protein; terminal domain; cov spike; spike protein ... See more keywords
Influencing factors of anti‐SARS‐CoV‐2‐spike‐IgG antibody titers in healthcare workers: A cross‐section study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28300
Abstract: Against the background of the current COVID‐19 infection dynamics with its rapid spread of SARS‐CoV‐2 variants of concern (VOC), the immunity and the vaccine prevention of healthcare workers (HCWs) against SARS‐CoV‐2 continues to be of… read more here.
Keywords: cov spike; vaccination; spike igg; anti sars ... See more keywords
Characterization of a SARS-CoV-2 spike protein reference material
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DOI: 10.1007/s00216-022-04000-y
Abstract: Development of diagnostic testing capability has advanced with unprecedented pace in response to the COVID-19 pandemic. An undesirable effect of such speed is a lack of standardization, often leading to unreliable test results. To assist… read more here.
Keywords: reference; sars cov; spike protein; mass ... See more keywords
Probing the competitive inhibitor efficacy of frog-skin alpha helical AMPs identified against ACE2 binding to SARS-CoV-2 S1 spike protein as therapeutic scaffold to prevent COVID-19
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DOI: 10.1007/s00894-022-05117-8
Abstract: In COVID-19 infection, the SARS-CoV-2 spike protein S1 interacts to the ACE2 receptor of human host, instigating the viral infection. To examine the competitive inhibitor efficacy of broad spectrum alpha helical AMPs extracted from frog… read more here.
Keywords: cov spike; spike protein; sars cov; dermaseptin ... See more keywords
Computer simulations on oxidative stress-induced reactions in SARS-CoV-2 spike glycoprotein: a multi-scale approach
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Diversity"
DOI: 10.1007/s11030-021-10373-6
Abstract: Abstract Oxidative stress, which occurs when an organism is exposed to an adverse stimulus that results in a misbalance of antioxidant and pro-oxidants species, is the common denominator of diseases considered as a risk factor… read more here.
Keywords: sars cov; stress; oxidative stress; cov spike ... See more keywords